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Solute carrier organic anion transporter family member 2A1

From Wikipedia, the free encyclopedia
(Redirected fromSLCO2A1)
Protein-coding gene in the species Homo sapiens
SLCO2A1
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

3MRR

Identifiers
AliasesSLCO2A1, MATR1, OATP2A1, PGT, PHOAR2, SLC21A2, solute carrier organic anion transporter family member 2A1, PHOAD
External IDsOMIM:601460;MGI:1346021;HomoloGene:38077;GeneCards:SLCO2A1;OMA:SLCO2A1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for SLCO2A1
Genomic location for SLCO2A1
Band3q22.1-q22.2Start133,932,701bp[1]
End134,052,184bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for SLCO2A1
Genomic location for SLCO2A1
Band9 F1|9 54.72 cMStart102,865,911bp[2]
End102,973,201bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lung

  • upper lobe of left lung

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • lower lobe of lung

  • seminal vesicula

  • cardia

  • left uterine tube

  • gastric mucosa

  • body of uterus
Top expressed in
  • decidua

  • right lung

  • gastrula

  • endothelial cell of lymphatic vessel

  • pyloric antrum

  • left lung

  • right lung lobe

  • left lung lobe

  • epithelium of stomach

  • epithelium of small intestine
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6578

24059

Ensembl

ENSG00000174640

ENSMUSG00000032548

UniProt

Q92959

Q9EPT5

RefSeq (mRNA)

NM_005630

NM_033314

RefSeq (protein)

NP_005621

NP_201571

Location (UCSC)Chr 3: 133.93 – 134.05 MbChr 9: 102.87 – 102.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier organic anion transporter family member 2A1, also known as theprostaglandin transporter (PGT), is aprotein that in humans is encoded by the SLCO2A1gene.[5]

This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanningorganic anion-transporting polypeptide superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance ofprostaglandins in numerous tissues.[5]

Clinical relevance

[edit]

Mutations in this gene have been shown to cause primaryhypertrophic osteoarthropathy,[6]specific form of chronic enteropathy.

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000174640 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000032548 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ab"Entrez Gene: Solute carrier organic anion transporter family, member 2A1". Retrieved2011-12-30.
  6. ^Zhang Z, Xia W, He J, Zhang Z, Ke Y, Yue H, Wang C, Zhang H, Gu J, Hu W, Fu W, Hu Y, Li M, Liu Y (January 2012)."Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy".American Journal of Human Genetics.90 (1):125–32.doi:10.1016/j.ajhg.2011.11.019.PMC 3257902.PMID 22197487.

Further reading

[edit]

External links

[edit]
  • Overview of all the structural information available in thePDB forUniProt:Q92959 (Solute carrier organic anion transporter family member 2A1) at thePDBe-KB.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

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SLC21–30
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SLC31–40
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SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)


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