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Large neutral amino acids transporter small subunit 2

From Wikipedia, the free encyclopedia
(Redirected fromSLC7A8)
Protein found in humans
SLC7A8
Identifiers
AliasesSLC7A8, LAT2, LPI-PC1, solute carrier family 7 member 8
External IDsOMIM:604235;MGI:1355323;HomoloGene:8166;GeneCards:SLC7A8;OMA:SLC7A8 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for SLC7A8
Genomic location for SLC7A8
Band14q11.2Start23,125,295bp[1]
End23,183,674bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for SLC7A8
Genomic location for SLC7A8
Band14|14 C2Start54,959,666bp[2]
End55,019,403bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • left uterine tube

  • beta cell

  • gastric mucosa

  • right ovary

  • human kidney

  • left ovary

  • oocyte

  • retinal pigment epithelium

  • decidua
Top expressed in
  • yolk sac

  • epithelium of lens

  • right kidney

  • lip

  • islet of Langerhans

  • gastrula

  • decidua

  • superior frontal gyrus

  • muscle of thigh

  • dentate gyrus of hippocampal formation granule cell
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23428

50934

Ensembl

ENSG00000092068

ENSMUSG00000022180

UniProt

Q9UHI5

Q9QXW9

RefSeq (mRNA)

NM_001267036
NM_001267037
NM_012244
NM_182728

NM_016972

RefSeq (protein)

NP_001253965
NP_001253966
NP_036376
NP_877392

NP_058668

Location (UCSC)Chr 14: 23.13 – 23.18 MbChr 14: 54.96 – 55.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Large neutral amino acids transporter small subunit 2 is aprotein that in humans is encoded by theSLC7A8gene.[5][6][7]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000092068 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000022180 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Borsani G, Bassi MT, Sperandeo MP, De Grandi A, Buoninconti A, Riboni M, Manzoni M, Incerti B, Pepe A, Andria G, Ballabio A, Sebastio G (Mar 1999). "SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance".Nat Genet.21 (3):297–301.doi:10.1038/6815.PMID 10080183.S2CID 38960307.
  6. ^Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M (Aug 1999)."Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids".J Biol Chem.274 (28):19738–44.doi:10.1074/jbc.274.28.19738.hdl:2445/177123.PMID 10391915.
  7. ^"Entrez Gene: SLC7A8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8".

Further reading

[edit]
By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
(24):
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
SLC41–48
(41):
(42):
(43):
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)


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