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Choline transporter-like protein 1

From Wikipedia, the free encyclopedia
(Redirected fromSLC44A1)
Mammalian protein found in Homo sapiens
SLC44A1
Identifiers
AliasesSLC44A1, CD92, CDW92, CHTL1, CTL1, solute carrier family 44 member 1, CONATOC
External IDsOMIM:606105;MGI:2140592;HomoloGene:11137;GeneCards:SLC44A1;OMA:SLC44A1 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for SLC44A1
Genomic location for SLC44A1
Band9q31.1-q31.2Start105,244,622bp[1]
End105,439,171bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for SLC44A1
Genomic location for SLC44A1
Band4|4 B2Start53,440,413bp[2]
End53,622,478bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • inferior ganglion of vagus nerve

  • internal globus pallidus

  • subthalamic nucleus

  • superior vestibular nucleus

  • external globus pallidus

  • pars reticulata

  • ventral tegmental area

  • mucosa of sigmoid colon

  • corpus epididymis
Top expressed in
  • hair follicle

  • left colon

  • urothelium

  • deep cerebellar nuclei

  • pyloric antrum

  • transitional epithelium of urinary bladder

  • medullary collecting duct

  • gastric mucosa

  • mucous cell of stomach

  • Paneth cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23446

100434

Ensembl

ENSG00000070214

ENSMUSG00000028412

UniProt

Q8WWI5

Q6X893

RefSeq (mRNA)

NM_001286730
NM_022109
NM_080546
NM_001330731

NM_001159633
NM_133891
NM_001374697

RefSeq (protein)

NP_001273659
NP_001317660
NP_536856

NP_001153105
NP_598652
NP_001361626

Location (UCSC)Chr 9: 105.24 – 105.44 MbChr 4: 53.44 – 53.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Choline transporter-like protein 1 is aprotein that in humans is encoded by theSLC44A1gene.[5][6][7]

Papillary glioneuronal tumors characteristically exhibit a gene fusion betweenSLC44A1 andPRKCA.[8][9][10] Loss of function mutations have been implicated in ethanolamine transport.[11]

See also

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References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000070214 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000028412 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Wille S, Szekeres A, Majdic O, Prager E, Staffler G, Stöckl J, Kunthalert D, Prieschl EE, Baumruker T, Burtscher H, Zlabinger GJ, Knapp W, Stockinger H (November 2001)."Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells".Journal of Immunology.167 (10):5795–5804.doi:10.4049/jimmunol.167.10.5795.PMID 11698453.
  6. ^O'Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM (February 2000)."An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins".Proceedings of the National Academy of Sciences of the United States of America.97 (4):1835–40.Bibcode:2000PNAS...97.1835O.doi:10.1073/pnas.030339697.PMC 26522.PMID 10677542.
  7. ^"Entrez Gene: SLC44A1 solute carrier family 44, member 1".
  8. ^Bridge JA, Liu XQ, Sumegi J, Nelson M, Reyes C, Bruch LA, Rosenblum M, Puccioni MJ, Bowdiono BS, McComb RD (2013)."Identification of a Novel, Recurrent SLC44A1-PRKCA Fusion in Papillary Glioneuronal Tumor".Brain Pathology.23 (2):121–128.doi:10.1111/j.1750-3639.2012.00612.x.PMC 8029478.PMID 22725730.
  9. ^Pages M, Lacroix L, Tauziede-Espariat A, Castel D, Daudigeos-Dubus E, Ridola V, et al. (2015)."Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion".Acta Neuropathologica Communications.3 85.doi:10.1186/s40478-015-0264-5.PMC 4681033.PMID 26671581. 85.
  10. ^Nagaishi M, Nobusawa S, Matsumura N, Kono F, Ishiuchi S, Abe T, Ebato M, Wang Y, Hyodo A, Yokoo H, Nakazato Y (2016). "SLC44A1 –PRKCA fusion in papillary and rosette-forming glioneuronal tumors".Journal of Clinical Neuroscience.23:73–75.doi:10.1016/j.jocn.2015.04.021.PMID 26260115.S2CID 140207877.
  11. ^Taylor A, Grapentine S, Ichhpuniani J, Bakovic M (2021)."Choline transporter-like proteins 1 and 2 are newly identified plasma membrane and mitochondrial ethanolamine transporters".J Biol Chem.296 100604.doi:10.1016/j.jbc.2021.100604.PMC 8081925.PMID 33789160.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Further reading

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External links

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1–50
51–100
101–150
151–200
201–250
251–300
301–350
By group
SLC1–10
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SLC11–20
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SLC21–30
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SLC31–40
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SLC41–48
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SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)


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