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Zinc transporter ZIP6

From Wikipedia, the free encyclopedia
(Redirected fromSLC39A6)
Protein found in humans
SLC39A6
Identifiers
AliasesSLC39A6, LIV-1, ZIP6, solute carrier family 39 member 6, LIV1
External IDsOMIM:608731;MGI:2147279;HomoloGene:8199;GeneCards:SLC39A6;OMA:SLC39A6 - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for SLC39A6
Genomic location for SLC39A6
Band18q12.2Start36,108,531bp[1]
End36,129,385bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for SLC39A6
Genomic location for SLC39A6
Band18|18 A2Start24,712,938bp[2]
End24,736,874bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • Epithelium of choroid plexus

  • retinal pigment epithelium

  • hair follicle

  • tibia

  • seminal vesicula

  • gingival epithelium

  • caput epididymis

  • epithelium of lactiferous gland

  • lactiferous duct
Top expressed in
  • hair follicle

  • superior cervical ganglion

  • saccule

  • primary oocyte

  • supraoptic nucleus

  • condyle

  • decidua

  • molar

  • otic vesicle

  • zygote
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25800

106957

Ensembl

ENSG00000141424

ENSMUSG00000024270

UniProt

Q13433

Q8C145

RefSeq (mRNA)

NM_001099406
NM_012319

NM_139143

RefSeq (protein)

NP_001092876
NP_036451

NP_631882

Location (UCSC)Chr 18: 36.11 – 36.13 MbChr 18: 24.71 – 24.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc transporter ZIP6 is aprotein that in humans is encoded by theSLC39A6gene.[5][6][7]

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003).[supplied by OMIM][7]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000141424 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000024270 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Taylor KM, Nicholson RI (Mar 2003)."The LZT proteins; the LIV-1 subfamily of zinc transporters".Biochim Biophys Acta.1611 (1–2):16–30.doi:10.1016/S0005-2736(03)00048-8.PMID 12659941.
  6. ^Taylor KM, Morgan HE, Johnson A, Hadley LJ, Nicholson RI (Sep 2003)."Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters".Biochem J.375 (Pt 1):51–9.doi:10.1042/BJ20030478.PMC 1223660.PMID 12839489.
  7. ^ab"Entrez Gene: SLC39A6 solute carrier family 39 (zinc transporter), member 6".

Further reading

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By group
SLC1–10
(1):
(2):
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SLC11–20
(11):
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SLC21–30
(21):
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SLC31–40
(31):
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SLC41–48
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SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)


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