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Zinc transporter ZIP4

From Wikipedia, the free encyclopedia
(Redirected fromSLC39A4)
Protein found in humans

SLC39A4
Identifiers
AliasesSLC39A4, AEZ, AWMS2, ZIP4, solute carrier family 39 member 4
External IDsOMIM:607059;MGI:1919277;HomoloGene:15638;GeneCards:SLC39A4;OMA:SLC39A4 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for SLC39A4
Genomic location for SLC39A4
Band8q24.3Start144,409,742bp[1]
End144,416,844bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for SLC39A4
Genomic location for SLC39A4
Band15|15 D3Start76,496,583bp[2]
End76,501,584bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • duodenum

  • mucosa of transverse colon

  • human kidney

  • renal cortex

  • body of stomach

  • left lobe of thyroid gland

  • fundus

  • right ovary

  • right lobe of thyroid gland

  • skin of abdomen
Top expressed in
  • jejunum

  • duodenum

  • yolk sac

  • ileum

  • choroid plexus of fourth ventricle

  • epithelium of small intestine

  • intestinal villus

  • left lobe of liver

  • right lung lobe

  • left colon
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55630

72027

Ensembl

ENSG00000147804
ENSG00000285243

ENSMUSG00000063354

UniProt

Q6P5W5

Q78IQ7

RefSeq (mRNA)

NM_001280557
NM_017767
NM_130849
NM_001374839

NM_028064

RefSeq (protein)

NP_001267486
NP_060237
NP_570901
NP_001361768

NP_082340

Location (UCSC)Chr 8: 144.41 – 144.42 MbChr 15: 76.5 – 76.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc transporter ZIP4 is atransmembrane protein which in humans is encoded by theSLC39A4gene. It is associated withacrodermatitis enteropathica.[5]

See also

[edit]

References

[edit]
  1. ^abcENSG00000285243 GRCh38: Ensembl release 89: ENSG00000147804, ENSG00000285243 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000063354 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Kambe T, Andrews GK (January 2009)."Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations".Molecular and Cellular Biology.29 (1):129–139.doi:10.1128/MCB.00963-08.PMC 2612479.PMID 18936158.

External links

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By group
SLC1–10
(1):
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SLC11–20
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SLC21–30
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SLC31–40
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SLC41–48
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SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)
Transition metal
Iron metabolism
Absorption in
duodenum
Iron(II) oxide:
Iron(III) oxide:
Other
Iron-binding proteins:
Copper metabolism
Zinc metabolism
Electrolyte
Sodium metabolism
Phosphate metabolism
Magnesium metabolism
Calcium metabolism


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