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Zinc transporter ZIP1

From Wikipedia, the free encyclopedia
(Redirected fromSLC39A1)
Protein found in humans
SLC39A1
Identifiers
AliasesSLC39A1, ZIP1, ZIRTL, solute carrier family 39 member 1
External IDsOMIM:604740;MGI:1353474;HomoloGene:40906;GeneCards:SLC39A1;OMA:SLC39A1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SLC39A1
Genomic location for SLC39A1
Band1q21.3Start153,959,099bp[1]
End153,968,184bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for SLC39A1
Genomic location for SLC39A1
Band3|3 F1Start90,155,479bp[2]
End90,160,919bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • placenta

  • Achilles tendon

  • upper lobe of left lung

  • right lung

  • stromal cell of endometrium

  • gallbladder

  • right adrenal gland

  • left adrenal gland

  • Descending thoracic aorta

  • ascending aorta
Top expressed in
  • prostate

  • umbilical cord

  • epidermis

  • lip

  • uterus

  • placenta

  • urinary bladder

  • gallbladder

  • duodenum

  • stomach
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27173

30791

Ensembl

ENSG00000143570

ENSMUSG00000052310

UniProt

Q9NY26

Q9QZ03

RefSeq (mRNA)
NM_014437
NM_001271957
NM_001271958
NM_001271959
NM_001271960

NM_001271961

NM_013901

RefSeq (protein)
NP_001258886
NP_001258887
NP_001258888
NP_001258889
NP_001258890

NP_055252

NP_038929

Location (UCSC)Chr 1: 153.96 – 153.97 MbChr 3: 90.16 – 90.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc transporter ZIP1 is aprotein that in humans is encoded by theSLC39A1gene.[5][6][7]

The protein ZIP1 is responsible for the active transport ofzinc intoprostate cells. In manyprostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.[8]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000143570 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000052310 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex".Genomics.62 (2):272–80.doi:10.1006/geno.1999.5993.PMID 10610721.
  6. ^Gaither LA, Eide DJ (Mar 2000)."Functional expression of the human hZIP2 zinc transporter".J Biol Chem.275 (8):5560–4.doi:10.1074/jbc.275.8.5560.PMID 10681536.
  7. ^"Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".
  8. ^Costello LC, Franklin RB (2006)."The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots".Mol. Cancer.5: 17.doi:10.1186/1476-4598-5-17.PMC 1481516.PMID 16700911.

Further reading

[edit]
By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
(24):
(25):
(26):
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(28):
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(30):
SLC31–40
(31):
(32):
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(38):
(39):
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SLC41–48
(41):
(42):
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(45):
(46):
(47):
(48):
SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)


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