Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

Putative sodium-coupled neutral amino acid transporter 10

From Wikipedia, the free encyclopedia
(Redirected fromSLC38A10)
Protein-coding gene in the species Homo sapiens
SLC38A10
Identifiers
AliasesSLC38A10, PP1744, solute carrier family 38 member 10
External IDsOMIM:616525;MGI:1919305;HomoloGene:41556;GeneCards:SLC38A10;OMA:SLC38A10 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for SLC38A10
Genomic location for SLC38A10
Band17q25.3Start81,244,811bp[1]
End81,295,547bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for SLC38A10
Genomic location for SLC38A10
Band11|11 E2Start119,994,786bp[2]
End120,042,172bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • anterior pituitary

  • body of pancreas

  • right lobe of liver

  • right lobe of thyroid gland

  • mucosa of transverse colon

  • apex of heart

  • right uterine tube

  • right coronary artery

  • left lobe of thyroid gland

  • granulocyte
Top expressed in
  • motor neuron

  • fossa

  • calvaria

  • aortic valve

  • ascending aorta

  • vestibular membrane of cochlear duct

  • Paneth cell

  • condyle

  • external carotid artery

  • iris
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

124565

72055

Ensembl

ENSG00000157637

ENSMUSG00000061306

UniProt

Q9HBR0

Q5I012

RefSeq (mRNA)

NM_001037984
NM_138570

NM_001164798
NM_001164799
NM_001164800
NM_001164801
NM_001164802

NM_024249
NM_001361696
NM_001361697
NM_001361698
NM_001361699

RefSeq (protein)

NP_001033073
NP_612637

NP_001158270
NP_001158271
NP_001158272
NP_001158273
NP_001158274

NP_077211
NP_001348625
NP_001348626
NP_001348627
NP_001348628

Location (UCSC)Chr 17: 81.24 – 81.3 MbChr 11: 119.99 – 120.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Putative sodium-coupled neutral amino acid transporter 10, also known assolute carrier family 38 member 10,[5] is aprotein that in humans is encoded by theSLC38A10gene.[6]

Cellular localization

[edit]

Cellular localization study of SLC38A10 protein was investigated on different cell lines and primary cortex neuronal cells using Immunocytochemistry and GFP SLC38A10 vector. SLC38A10 localized on Golgi apparatus and ER organelles.[7]

Recent study on SLC38A10 knockout model provided some insight on possible association with p53 protein and cell survival.[8]

Cancer

[edit]

A SLC38A family member has been observed progressively downregulated inHuman papillomavirus-positiveneoplastic keratinocytes derived from uterine cervicalpreneoplastic lesions at different levels of malignancy.[9] For this reason, SLC38A is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervicalpreneoplastic lesions progression.[9]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000157637 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000061306 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"SLC38A10 - Function".www.nextprot.org. Retrieved2021-11-29.
  6. ^"Entrez Gene: solute carrier family 38, member 10". Retrieved2011-08-30.
  7. ^Tripathi R, Hosseini K, Arapi V, Fredriksson R, Bagchi S (December 2019)."SLC38A10 (SNAT10) is Located in ER and Golgi Compartments and Has a Role in Regulating Nascent Protein Synthesis".International Journal of Molecular Sciences.20 (24): 6265.doi:10.3390/ijms20246265.PMC 6940841.PMID 31842320.
  8. ^Tripathi R, Aggarwal T, Fredriksson R (2021)."SLC38A10 Transporter Plays a Role in Cell Survival Under Oxidative Stress and Glutamate Toxicity".Frontiers in Molecular Biosciences.8: 671865.doi:10.3389/fmolb.2021.671865.ISSN 2296-889X.PMC 8133219.PMID 34026845.
  9. ^abRotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, et al. (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes".Journal of Cellular Physiology.230 (4):806–12.doi:10.1002/jcp.24808.hdl:11392/2066612.PMID 25205602.S2CID 24986454.

Further reading

[edit]
By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
(24):
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
SLC41–48
(41):
(42):
(43):
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)
Stub icon

This article on agene on humanchromosome 17 is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Putative_sodium-coupled_neutral_amino_acid_transporter_10&oldid=1190498709"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2025 Movatter.jp