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SLC38A1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
SLC38A1
Identifiers
AliasesSLC38A1, ATA1, NAT2, SAT1, SNAT1, solute carrier family 38 member 1
External IDsOMIM:608490;MGI:2145895;HomoloGene:12745;GeneCards:SLC38A1;OMA:SLC38A1 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for SLC38A1
Genomic location for SLC38A1
Band12q13.11Start46,183,063bp[1]
End46,270,017bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for SLC38A1
Genomic location for SLC38A1
Band15|15 F1Start96,469,299bp[2]
End96,540,794bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lateral nuclear group of thalamus

  • seminal vesicula

  • superficial temporal artery

  • mucosa of sigmoid colon

  • middle temporal gyrus

  • pars compacta

  • body of tongue

  • Brodmann area 23

  • cerebellar vermis

  • external globus pallidus
Top expressed in
  • deep cerebellar nuclei

  • inferior colliculi

  • retinal pigment epithelium

  • habenula

  • dorsal tegmental nucleus

  • medial vestibular nucleus

  • superior colliculus

  • cerebellar vermis

  • pontine nuclei

  • ventral tegmental area
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

81539

105727

Ensembl

ENSG00000111371

ENSMUSG00000023169

UniProt

Q9H2H9

Q8K2P7

RefSeq (mRNA)
NM_001077484
NM_001278387
NM_001278388
NM_001278389
NM_001278390

NM_030674

NM_001166456
NM_001166458
NM_134086

RefSeq (protein)
NP_001070952
NP_001265316
NP_001265317
NP_001265318
NP_001265319

NP_109599

NP_001159928
NP_001159930
NP_598847

Location (UCSC)Chr 12: 46.18 – 46.27 MbChr 15: 96.47 – 96.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium-coupled neutral amino acid transporter 1 is aprotein that in humans is encoded by theSLC38A1gene.[5][6]

Amino acid transporters play essential roles in the uptake ofnutrients, production of energy, chemical metabolism,detoxification, andneurotransmitter cycling. SLC38A1 is an important transporter ofglutamine, an intermediate in the detoxification ofammonia and the production ofurea. Glutamine serves as a precursor for the synaptic transmitter,glutamate (Gu et al., 2001).[supplied by OMIM][6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000111371Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000023169Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Wang H, Huang W, Sugawara M, Devoe LD, Leibach FH, Prasad PD, Ganapathy V (Sep 2000). "Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta".Biochem Biophys Res Commun.273 (3):1175–9.doi:10.1006/bbrc.2000.3061.PMID 10891391.
  6. ^ab"Entrez Gene: SLC38A1 solute carrier family 38, member 1".

Further reading

[edit]


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