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Sodium-dependent phosphate transport protein 2B

From Wikipedia, the free encyclopedia
(Redirected fromSLC34A2)
Protein-coding gene in the species Homo sapiens

SLC34A2
Identifiers
AliasesSLC34A2, NAPI-3B, NAPI-IIb, NPTIIb, solute carrier family 34 member 2, PULAM
External IDsOMIM:604217;MGI:1342284;HomoloGene:2297;GeneCards:SLC34A2;OMA:SLC34A2 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for SLC34A2
Genomic location for SLC34A2
Band4p15.2Start25,648,011bp[1]
End25,678,748bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for SLC34A2
Genomic location for SLC34A2
Band5 C1|5 28.92 cMStart53,195,423bp[2]
End53,229,006bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lower lobe of lung

  • palpebral conjunctiva

  • upper lobe of lung

  • upper lobe of left lung

  • bronchial epithelial cell

  • right lung

  • right uterine tube

  • endometrium

  • minor salivary glands

  • right lobe of thyroid gland
Top expressed in
  • left lung

  • left lung lobe

  • right lung

  • right lung lobe

  • ileum

  • jejunum

  • spermatocyte

  • spermatid

  • corneal stroma

  • morula
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10568

20531

Ensembl

ENSG00000157765

ENSMUSG00000029188

UniProt

O95436

Q9DBP0

RefSeq (mRNA)

NM_006424
NM_001177998
NM_001177999

NM_011402

RefSeq (protein)

NP_001171469
NP_001171470
NP_006415

NP_035532

Location (UCSC)Chr 4: 25.65 – 25.68 MbChr 5: 53.2 – 53.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium-dependent phosphate transport protein 2B (NaPi2b) is aprotein that in humans is encoded by theSLC34A2gene.[5][6][7]

Clinical significance

[edit]

Sodium-dependent phosphate transport protein 2b (NaPi2b) is atumor-associated antigen.[8]

As of April 2023,upifitamab rilsodotin, anantibody-drug conjugate (ADC) targeting NaPi2b, is in Phase 3 clinical trials for recurrent platinum-sensitive ovarian cancer.[9]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000157765 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000029188 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Feild JA, Zhang L, Brun KA, Brooks DP, Edwards RM (May 1999). "Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine".Biochemical and Biophysical Research Communications.258 (3):578–582.doi:10.1006/bbrc.1999.0666.PMID 10329428.
  6. ^Xu H, Bai L, Collins JF, Ghishan FK (December 1999). "Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)".Genomics.62 (2):281–284.doi:10.1006/geno.1999.6009.PMID 10610722.
  7. ^"Entrez Gene: SLC34A2 solute carrier family 34 (sodium phosphate), member 2".
  8. ^Yin BW, Kiyamova R, Chua R, Caballero OL, Gout I, Gryshkova V, et al. (February 2008)."Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas".Cancer Immunity.8: 3.PMC 2935786.PMID 18251464.
  9. ^Clinical trial numberNCT05329545 for "Upifitamab Rilsodotin Maintenance in Platinum-Sensitive Recurrent Ovarian Cancer (UP-NEXT)." atClinicalTrials.gov

Further reading

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By group
SLC1–10
(1):
(2):
(3):
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(5):
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SLC11–20
(11):
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SLC21–30
(21):
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SLC31–40
(31):
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SLC41–48
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SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)
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