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Long-chain fatty acid transport protein 4

From Wikipedia, the free encyclopedia
(Redirected fromSLC27A4)
Protein-coding gene in the species Homo sapiens
SLC27A4
Identifiers
AliasesSLC27A4, ACSVL4, FATP4, IPS, solute carrier family 27 member 4
External IDsOMIM:604194;MGI:1347347;HomoloGene:68437;GeneCards:SLC27A4;OMA:SLC27A4 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for SLC27A4
Genomic location for SLC27A4
Band9q34.11Start128,340,527bp[1]
End128,361,470bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SLC27A4
Genomic location for SLC27A4
Band2 B|2 20.64 cMStart29,692,646bp[2]
End29,707,534bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • jejunal mucosa

  • duodenum

  • skin of arm

  • mucosa of ileum

  • prefrontal cortex

  • right frontal lobe

  • skin of leg

  • Brodmann area 9

  • Hypothalamus
Top expressed in
  • lip

  • granulocyte

  • jejunum

  • duodenum

  • ileum

  • skin of external ear

  • esophagus

  • pontine nuclei

  • skin of abdomen

  • medial dorsal nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10999

26569

Ensembl

ENSG00000167114

ENSMUSG00000059316

UniProt

Q6P1M0

Q91VE0

RefSeq (mRNA)

NM_005094

NM_011989

RefSeq (protein)

NP_005085
NP_005085.2

NP_036119

Location (UCSC)Chr 9: 128.34 – 128.36 MbChr 2: 29.69 – 29.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Long-chain fatty acid transport protein 4 is aprotein that in humans is encoded by theSLC27A4gene.[5][6] This membrane protein is also called FATP4 or ACSVL5 (very long chain fatty acyl-CoA synthetase 5). The purified protein shows enzyme activity (EC 6.2.1.3), esterifying long and very long chain fatty acids with Coenzyme A.[7] It is debated whether it is also a fatty acid transporter at the plasma membrane.[8]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000167114 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000059316 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Fitscher BA, Riedel HD, Young KC, Stremmel W (Dec 1998). "Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4)".Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.1443 (3):381–5.doi:10.1016/s0167-4781(98)00231-0.PMID 9878842.
  6. ^"Entrez Gene: SLC27A4 solute carrier family 27 (fatty acid transporter), member 4".
  7. ^Hall AM, Wiczer BM, Herrmann T, Stremmel W, Bernlohr DA (Mar 2005)."Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice".The Journal of Biological Chemistry.280 (12):11948–54.doi:10.1074/jbc.M412629200.PMID 15653672.
  8. ^Watkins PA (Jan 2008)."Very-long-chain acyl-CoA synthetases".The Journal of Biological Chemistry.283 (4):1773–7.doi:10.1074/jbc.R700037200.PMID 18024425.

Further reading

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By group
SLC1–10
(1):
(2):
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SLC11–20
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SLC21–30
(21):
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SLC31–40
(31):
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SLC41–48
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SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)
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