Solute carrier family 26 member 6 is aprotein that in humans is encoded by theSLC26A6gene.[5][6][7] It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.[8]
This gene belongs to thesolute carrier 26 family, whose members encodeanion transporter proteins. This particular family member encodes a protein involved intransportingchloride,oxalate,sulfate andbicarbonate. Several alternatively splicedtranscript variants of this gene, encoding distinctisoforms, have been described, but the full-length nature of some of these variants has not been determined.[7]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lohi H, Kujala M, Kerkelä E, Saarialho-Kere U, Kestilä M, Kere J (November 2000). "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger".Genomics.70 (1):102–112.doi:10.1006/geno.2000.6355.PMID11087667.
^Waldegger S, Moschen I, Ramirez A, Smith RJ, Ayadi H, Lang F, Kubisch C (February 2001). "Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family".Genomics.72 (1):43–50.doi:10.1006/geno.2000.6445.PMID11247665.
^Wang Z, Wang T, Petrovic S, Tuo B, Riederer B, Barone S, et al. (April 2005). "Renal and intestinal transport defects in Slc26a6-null mice".American Journal of Physiology. Cell Physiology. 4.288 (4):C957 –C965.doi:10.1152/ajpcell.00505.2004.PMID15574486.S2CID23214608.
Ignatovich O, Tomlinson IM, Popov AV, Brüggemann M, Winter G (November 1999). "Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire".Journal of Molecular Biology.294 (2):457–465.doi:10.1006/jmbi.1999.3243.PMID10610771.
Xie Q, Welch R, Mercado A, Romero MF, Mount DB (October 2002). "Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1".American Journal of Physiology. Renal Physiology.283 (4):F826 –F838.doi:10.1152/ajprenal.00079.2002.PMID12217875.
Kujala M, Tienari J, Lohi H, Elomaa O, Sariola H, Lehtonen E, Kere J (2006). "SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney".Nephron. Experimental Nephrology.101 (2):e50 –e58.doi:10.1159/000086345.PMID15956810.S2CID26671784.
Alper SL, Stewart AK, Chernova MN, et al. (2007). "Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides".Epithelial Anion Transport in Health and Disease: The Role of the SLC26 Transporters Family. Novartis Foundation Symposia. Vol. 273. pp. 107–19, discussion 119–25,261–4.doi:10.1002/0470029579.ch8.ISBN9780470016244.PMID17120764.
