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SLC23A2

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
SLC23A2
Identifiers
AliasesSLC23A2, NBTL1, SLC23A1, SVCT2, YSPL2, hSVCT2, solute carrier family 23 member 2
External IDsOMIM:603791;MGI:1859682;HomoloGene:68440;GeneCards:SLC23A2;OMA:SLC23A2 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SLC23A2
Genomic location for SLC23A2
Band20p13Start4,852,356bp[1]
End5,010,293bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SLC23A2
Genomic location for SLC23A2
Band2|2 F2Start131,894,416bp[2]
End131,987,028bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right adrenal cortex

  • left adrenal cortex

  • lateral nuclear group of thalamus

  • Brodmann area 10

  • Epithelium of choroid plexus

  • paraflocculus of cerebellum

  • cerebellar vermis

  • pars compacta

  • right lobe of liver

  • subthalamic nucleus
Top expressed in
  • choroid plexus of fourth ventricle

  • secondary oocyte

  • gastrula

  • zygote

  • primary visual cortex

  • perirhinal cortex

  • CA3 field

  • entorhinal cortex

  • Epithelium of choroid plexus

  • superior frontal gyrus
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9962

54338

Ensembl

ENSG00000089057

ENSMUSG00000027340

UniProt

Q9UGH3

Q9EPR4

RefSeq (mRNA)

NM_005116
NM_203327

NM_018824
NM_001355430
NM_001355431

RefSeq (protein)

NP_005107
NP_976072

NP_061294
NP_001342359
NP_001342360

Location (UCSC)Chr 20: 4.85 – 5.01 MbChr 2: 131.89 – 131.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 23 member 2 is aprotein that in humans is encoded by theSLC23A2gene.[5][6][7]

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1.[7]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000089057 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000027340 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ (Dec 1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters".Biochim Biophys Acta.1442 (2–3):353–60.doi:10.1016/S0167-4781(98)00151-1.PMID 9804989.
  6. ^Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (Jun 1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters".Nature.399 (6731):70–5.Bibcode:1999Natur.399...70T.doi:10.1038/19986.PMID 10331392.S2CID 4425479.
  7. ^ab"Entrez Gene: SLC23A2 solute carrier family 23 (nucleobase transporters), member 2".

Further reading

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

By group
SLC1–10
(1):
(2):
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SLC11–20
(11):
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(15):
(16):
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SLC21–30
(21):
(22):
(23):
(24):
(25):
(26):
(27):
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SLC31–40
(31):
(32):
(33):
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SLC41–48
(41):
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(48):
SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)


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