The encoded protein is an integral protein of the plasma membrane containing 12 transmembrane segments. The first functional designation of this protein was OCTN1 ("organic cation transporter, novel, type 1"), but efficiency of transport for organic cations (e.g.,tetraethylammonium) is very low. The transport efficiency for carnitine is also negligible. Instead, the protein is responsible for thecotransport of sodium ions andergothioneine, which is anantioxidant, into cells.[7] Thus, a more appropriate functional designation is ETT ("ergothioneine transporter").[5]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
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Tamai I, Yabuuchi H, Nezu J, Sai Y, Oku A, Shimane M, et al. (Dec 1997). "Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1".FEBS Letters.419 (1):107–111.doi:10.1016/S0014-5793(97)01441-5.PMID9426230.S2CID35546307.
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Urakami Y, Okuda M, Masuda S, Saito H, Inui KI (Nov 1998). "Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs".The Journal of Pharmacology and Experimental Therapeutics.287 (2):800–805.PMID9808712.
Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, et al. (May 1999). "Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations".The Journal of Pharmacology and Experimental Therapeutics.289 (2):768–773.PMID10215651.
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Tokuhiro S, Yamada R, Chang X, Suzuki A, Kochi Y, Sawada T, et al. (Dec 2003). "An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis".Nature Genetics.35 (4):341–348.doi:10.1038/ng1267.PMID14608356.S2CID21564858.
Kawasaki Y, Kato Y, Sai Y, Tsuji A (Dec 2004). "Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population".Journal of Pharmaceutical Sciences.93 (12):2920–2926.doi:10.1002/jps.20190.PMID15459889.
