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Natural resistance-associated macrophage protein 1

From Wikipedia, the free encyclopedia
(Redirected fromSLC11A1)
Protein-coding gene in the species Homo sapiens
SLC11A1
Identifiers
AliasesSLC11A1, LSH, NRAMP, NRAMP1, solute carrier family 11 member 1
External IDsOMIM:600266;MGI:1345275;HomoloGene:73884;GeneCards:SLC11A1;OMA:SLC11A1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for SLC11A1
Genomic location for SLC11A1
Band2q35Start218,382,029bp[1]
End218,396,894bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for SLC11A1
Genomic location for SLC11A1
Band1 C3|1 38.54 cMStart74,414,354bp[2]
End74,425,221bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lung

  • upper lobe of left lung

  • granulocyte

  • monocyte

  • blood

  • spleen

  • buccal mucosa cell

  • left uterine tube

  • left adrenal cortex

  • bone marrow cell
Top expressed in
  • granulocyte

  • stroma of bone marrow

  • spleen

  • internal carotid artery

  • mesenteric lymph nodes

  • tibiofemoral joint

  • morula

  • ciliary body

  • blood

  • carotid body
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6556

18173

Ensembl

ENSG00000018280

ENSMUSG00000026177

UniProt

P49279

P41251

RefSeq (mRNA)

NM_000578
NM_001032220

NM_013612

RefSeq (protein)

NP_000569

NP_038640

Location (UCSC)Chr 2: 218.38 – 218.4 MbChr 1: 74.41 – 74.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Natural resistance-associated macrophage protein 1 is aprotein that in humans is encoded by theSLC11A1gene.[5][6][7]

Function

[edit]

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens.Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, andinflammatory diseases such asrheumatoid arthritis andCrohn's disease.[8] Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.[7]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000018280 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000026177 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Cellier M, Govoni G, Vidal S, Kwan T, Groulx N, Liu J, Sanchez F, Skamene E, Schurr E, Gros P (November 1994)."Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression".The Journal of Experimental Medicine.180 (5):1741–52.doi:10.1084/jem.180.5.1741.PMC 2191750.PMID 7964458.
  6. ^Kishi F (November 1994). "Isolation and characterization of human Nramp cDNA".Biochemical and Biophysical Research Communications.204 (3):1074–80.doi:10.1006/bbrc.1994.2572.PMID 7980580.
  7. ^ab"Entrez Gene: SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1".
  8. ^Teras IuKh, Ryĭgas EM, Kazakova II, Ranne KhP, Trapido LE (1980). "[Detection of Trichomonas in the bronchi, sputum and oral cavity in various lung diseases]".Terapevticheskii Arkhiv.52 (3):123–5.PMID 7385031.

Further reading

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
(24):
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
SLC41–48
(41):
(42):
(43):
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)
Transition metal
Iron metabolism
Absorption in
duodenum
Iron(II) oxide:
Iron(III) oxide:
Other
Iron-binding proteins:
Copper metabolism
Zinc metabolism
Electrolyte
Sodium metabolism
Phosphate metabolism
Magnesium metabolism
Calcium metabolism


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