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Ileal sodium/bile acid cotransporter

From Wikipedia, the free encyclopedia
(Redirected fromSLC10A2)
Protein-coding gene in the species Homo sapiens
SLC10A2
Identifiers
AliasesSLC10A2, ASBT, IBAT, ISBT, NTCP2, PBAM, solute carrier family 10 member 2, Ileal bile acid transporter, PBAM1
External IDsOMIM:601295;MGI:1201406;HomoloGene:390;GeneCards:SLC10A2;OMA:SLC10A2 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for SLC10A2
Genomic location for SLC10A2
Band13q33.1Start103,043,998bp[1]
End103,066,417bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for SLC10A2
Genomic location for SLC10A2
Band8 A1.1|8 2.16 cMStart5,133,219bp[2]
End5,155,351bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of ileum

  • jejunal mucosa

  • duodenum

  • kidney tubule

  • testicle

  • glomerulus

  • metanephric glomerulus

  • human kidney

  • gallbladder

  • gonad
Top expressed in
  • proximal tubule

  • human kidney

  • right kidney

  • ileum

  • Paneth cell

  • lumbar spinal ganglion

  • left lobe of liver

  • lumbar subsegment of spinal cord

  • intestinal villus

  • jejunum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6555

20494

Ensembl

ENSG00000125255

ENSMUSG00000023073

UniProt

Q12908

P70172

RefSeq (mRNA)

NM_000452

NM_011388

RefSeq (protein)

NP_000443

NP_035518

Location (UCSC)Chr 13: 103.04 – 103.07 MbChr 8: 5.13 – 5.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ileal sodium/bile acid cotransporter, also known asapical sodium–bile acid transporter (ASBT) andileal bile acid transporter (IBAT), is abile acid:sodium symporterprotein that in humans is encoded by theSLC10A2gene.[5][6]

ASBT/IBAT is most highly expressed in theileum, where it is found on thebrush border membrane ofenterocytes. It is responsible for the initial uptake ofbile acids, particularly conjugated bile acids, from the intestine as part of theirenterohepatic circulation.[7]

As a drug target

[edit]

Severalmedications to inhibit IBAT are underdevelopment. They includeelobixibat, under development for the treatment ofconstipation andirritable bowel syndrome,[8] andvolixibat, under development for the treatment ofnonalcoholic steatohepatitis.[9]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000125255 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000023073 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Wong MH, Rao PN, Pettenati MJ, Dawson PA (May 1996). "Localization of the ileal sodium-bile acid cotransporter gene (SLC10A2) to human chromosome 13q33".Genomics.33 (3):538–40.doi:10.1006/geno.1996.0233.PMID 8661017.
  6. ^"Entrez Gene: SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2".
  7. ^Dawson PA (2011). "Role of the Intestinal Bile Acid Transporters in Bile Acid and Drug Disposition".Drug Transporters. Handbook of Experimental Pharmacology. Vol. 201. pp. 169–203.doi:10.1007/978-3-642-14541-4_4.ISBN 978-3-642-14540-7.PMC 3249407.PMID 21103970.
  8. ^Acosta A, Camilleri M (July 2014)."Elobixibat and its potential role in chronic idiopathic constipation".Therapeutic Advances in Gastroenterology.7 (4):167–75.doi:10.1177/1756283X14528269.PMC 4107709.PMID 25057297.
  9. ^Chitnis D (2016-08-03),"FDA grants fast track status to volixibat",Internal Medicine News Digital Network, retrieved2016-08-14.

Further reading

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

By group
SLC1–10
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SLC11–20
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SLC21–30
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SLC31–40
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SLC41–48
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SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)


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