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SL-75102

Српски / srpski

From Wikipedia, the free encyclopedia

SL-75102
Names

IUPAC name 4-[[(4-Chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanoic acid
Other names Progabide acid; LS-187121; SL-75-102-00
Identifiers
CAS Number	62665-97-8^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:368340
ChEMBL	ChEMBL160058
ChemSpider	20121433
PubChem CID	6140507
UNII	74JC6VM0KD^Y
InChI InChI=1S/C17H15ClFNO3/c18-12-5-3-11(4-6-12)17(20-9-1-2-16(22)23)14-10-13(19)7-8-15(14)21/h3-8,10,21H,1-2,9H2,(H,22,23)/b20-17+ Key: RRAXPPHKWFOGGL-LVZFUZTISA-N
SMILES c1cc(ccc1/C(=N\CCCC(=O)O)/c2cc(ccc2O)F)Cl
Properties
Chemical formula	C₁₇H₁₅ClFNO₃
Molar mass	335.76 g·mol⁻¹
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). Infobox references

Chemical compound

SL-75102, orprogabide acid, is anactive metabolite ofprogabide and ananticonvulsant GABA receptor agonist.^[1]^[2]

References

^Hamberger, C.; Barre, J.; Brandebourger, M.; Urien, S.; Taiclet, A.; Thenot, J. P.; Tillement, J. P. (April 1987). "Progabide and SL 75102 binding to plasma proteins and red blood cells in humans".Int J Clin Pharmacol Ther Toxicol.25 (4):178–84.PMID 3583466.
^Kubová, H.; Haugvicová, R.; Mares, P. (1997). "Anticonvulsant effect of SL 75 102 in adult and immature rats".Physiol Res.46 (1):73–6.PMID 9728525.

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GABA receptor modulators

GABA_ATooltip γ-Aminobutyric acid A receptor

Positive modulators (abridged; seehere for a full list):α-EMTBL
Alcohols (e.g.,drinking alcohol,2M2B)
Anabolic steroids
Avermectins (e.g.,ivermectin)
Barbiturates (e.g.,phenobarbital)
Benzodiazepines (e.g.,diazepam)
Bromide compounds (e.g.,potassium bromide)
Carbamates (e.g.,meprobamate)
Carbamazepine
Chloralose
Chlormezanone
Clomethiazole
Dihydroergolines (e.g.,ergoloid (dihydroergotoxine))
Etazepine
Etifoxine
Fenamates (e.g.,mefenamic acid)
Flavonoids (e.g.,apigenin,hispidulin)
Fluoxetine
Flupirtine
Imidazoles (e.g.,etomidate)
Kava constituents (e.g.,kavain)
Lanthanum
Loreclezole
Monastrol
Neuroactive steroids (e.g.,allopregnanolone,cholesterol,THDOC)
Niacin
Niacinamide
Nonbenzodiazepines (e.g.,β-carbolines (e.g.,abecarnil),cyclopyrrolones (e.g.,zopiclone),imidazopyridines (e.g.,zolpidem),pyrazolopyrimidines (e.g.,zaleplon))
Norfluoxetine
Petrichloral
Phenols (e.g.,propofol)
Phenytoin
Piperidinediones (e.g.,glutethimide)
Propanidid
Pyrazolopyridines (e.g.,etazolate)
Quinazolinones (e.g.,methaqualone)
Retigabine (ezogabine)
ROD-188
Skullcap constituents (e.g.,baicalin)
Stiripentol
Sulfonylalkanes (e.g.,sulfonmethane (sulfonal))
Topiramate
Valerian constituents (e.g.,valerenic acid)
Volatiles/gases (e.g.,chloral hydrate,chloroform,diethyl ether,paraldehyde,sevoflurane)

GABA_A-ρTooltip γ-Aminobutyric acid A-rho receptor

Negative modulators:5α-Dihydroprogesterone
Bilobalide
Loreclezole
Picrotoxin (picrotin,picrotoxinin)
Pregnanolone
ROD-188
THDOC
Zinc

GABA_BTooltip γ-Aminobutyric acid B receptor

Negative modulators:Compound 14

See also: Receptor/signaling modulators; GABA_A receptor positive modulators; GABA metabolism/transport modulators

Thisanticonvulsant-related article is astub. You can help Wikipedia byexpanding it.

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