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SKF-97,541

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Chemical compound

Pharmaceutical compound

SKF-97,541
Clinical data

ATC code	none
Identifiers
IUPAC name 3-aminopropyl(methyl)phosphinic acid
CAS Number	127729-35-5^Y
PubChemCID	5230
IUPHAR/BPS	1080
ChemSpider	5040^Y
ChEMBL	ChEMBL112710
CompTox Dashboard(EPA)	DTXSID80925969
ECHA InfoCard	100.229.655
Chemical and physical data
Formula	C₄H₁₂NO₂P
Molar mass	137.119 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CP(=O)(CCCN)O
InChI InChI=1S/C4H12NO2P/c1-8(6,7)4-2-3-5/h2-5H2,1H3,(H,6,7)^N Key:NHVRIDDXGZPJTJ-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

SKF-97,541 is a compound used in scientific research which acts primarily as a selectiveGABA_B receptor agonist.^[1] It hassedative effects in animal studies and is widely used in research into potential treatment of various types ofdrug addiction.^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9]

References

[edit]

^Seabrook GR, Howson W, Lacey MG (December 1990)."Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices".British Journal of Pharmacology.101 (4):949–57.doi:10.1111/j.1476-5381.1990.tb14186.x.PMC 1917862.PMID 1964824.
^Jackson GL, Kuehl D (May 2002). "The GABA(B) antagonist CGP 52432 attenuates the stimulatory effect of the GABA(B) agonist SKF 97541 on luteinizing hormone secretion in the male sheep".Experimental Biology and Medicine.227 (5):315–20.doi:10.1177/153537020222700503.PMID 11976401.S2CID 35467974.
^Besheer J, Lepoutre V, Hodge CW (July 2004). "GABA(B) receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice".Psychopharmacology.174 (3):358–66.doi:10.1007/s00213-003-1769-3.PMID 14985930.S2CID 25036152.
^Carter LP, Chen W, Coop A, Koek W, France CP (May 2006). "Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348".European Journal of Pharmacology.538 (1–3):85–93.doi:10.1016/j.ejphar.2006.03.039.PMID 16647701.
^Koek W, Mercer SL, Coop A (June 2007). "Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348".Psychopharmacology.192 (3):407–14.doi:10.1007/s00213-007-0718-y.PMID 17277933.S2CID 25049526.
^Koek W, Mercer SL, Coop A, France CP (September 2009)."Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348)".The Journal of Pharmacology and Experimental Therapeutics.330 (3):876–83.doi:10.1124/jpet.109.151845.PMC 2729800.PMID 19564487.
^Frankowska M, Nowak E, Filip M (2009). "Effects of GABAB receptor agonists on cocaine hyperlocomotor and sensitizing effects in rats".Pharmacological Reports.61 (6):1042–9.doi:10.1016/s1734-1140(09)70166-5.PMID 20081239.S2CID 4723878.
^Ranson DC, Ayoub SS, Corcoran O, Casalotti SO (2020)."Pharmacological targeting of the GABA B receptor alters Drosophila's behavioural responses to alcohol".Addiction Biology.25 (2) e12725.doi:10.1111/adb.12725.PMC 7050513.PMID 30761704.
^Gawlińska K, Jastrzębska J, Gamberini S, Gawliński D, Pieniążek R, Suder A, Wydra K, Frankowska M (September 2020). "The impact of GABAB receptors and their pharmacological stimulation on cocaine reinforcement and drug-seeking behaviors in a rat model of depression".European Journal of Pharmacology.883 173324.doi:10.1016/j.ejphar.2020.173324.PMID 32621910.S2CID 220348380.

Hypnotics/sedatives (N05C)

GABA_A

Alcohols	2M2B Chloralodol Ethanol (alcohol) Diethylpropanediol Ethchlorvynol Methylpentynol Trichloroethanol
Barbiturates	Allobarbital Amobarbital Aprobarbital Barbital Butabarbital Butobarbital Cyclobarbital Ethallobarbital Heptabarb Hexobarbital Mephobarbital Methohexital Narcobarbital Pentobarbital Phenallymal Phenobarbital Propylbarbital Proxibarbal Reposal Secobarbital Talbutal Thiamylal Thiopental Thiotetrabarbital Vinbarbital Vinylbital
Benzodiazepines	Brotizolam Cinolazepam Climazolam Clonazolam Doxefazepam Estazolam Flubromazolam Flunitrazolam Flunitrazepam Flurazepam Flutemazepam Flutoprazepam Loprazolam Lormetazepam Midazolam Nimetazepam Nitemazepam Nitrazepam Nitrazolam Quazepam Temazepam Triazolam
Carbamates	Carisoprodol Emylcamate Ethinamate Hexapropymate Meprobamate Methocarbamol Phenprobamate Procymate Tybamate
Imidazoles	Etomidate Metomidate Propoxate
Monoureides	Acecarbromal Apronal (apronalide) Bromisoval Capuride Carbromal Ectylurea
Neurosteroids	Acebrochol Alfadolone Alfaxolone Brexanolone (allopregnanolone) Eltanolone (pregnanolone) Ganaxolone Hydroxydione Minaxolone Progesterone Renanolone Zuranolone
Nonbenzodiazepines	Eszopiclone Indiplon Lirequinil Necopidem Pagoclone Pazinaclone Saripidem Suproclone Suriclone Zaleplon Zolpidem Zopiclone
Phenols	Cipepofol (ciprofol) Fospropofol Propofol Propofol hemisuccinate
Piperidinediones	Glutethimide Methyprylon Piperidione Pyrithyldione
Quinazolinones	Afloqualone Cloroqualone Diproqualone Etaqualone Mebroqualone Mecloqualone Methaqualone Methylmethaqualone Nitromethaqualone SL-164
Others	Acetophenone Acetylglycinamide chloral hydrate Bromide compounds Lithium bromide Potassium bromide Sodium bromide Centalun Chloral betaine Chloral hydrate Chloralose Clomethiazole Dichloralphenazone Gaboxadol (THIP) Ibotenic acid (Amanita muscaria) Kavalactones Loreclezole Muscimol (Amanita muscaria) Paraldehyde Petrichloral Sesquiterpene Isovaleramide Isovaleric acid Valerenic acid Sulfonylalkanes Sulfonmethane (sulfonal) Tetronal Trional Triclofos

GABA_B

H₁

Antihistamines	Captodiame Cyproheptadine Diphenhydramine Doxylamine Hydroxyzine Methapyrilene Perlapine Pheniramine Promethazine Propiomazine
Antidepressants	Serotonin antagonists and reuptake inhibitors Etoperidone Nefazodone Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine, etc. Tetracyclic antidepressants Mianserin Mirtazapine, etc.
Antipsychotics	Typical antipsychotics Chlorpromazine Thioridazine, etc. Atypical antipsychotics Olanzapine Quetiapine Risperidone, etc.

α₂-Adrenergic

5-HT_2A

Antidepressants	Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine, etc. Tetracyclic antidepressants Mianserin Mirtazapine, etc.
Antipsychotics	Typical antipsychotics Chlorpromazine Thioridazine, etc. Atypical antipsychotics Olanzapine Quetiapine Risperidone, etc.
Others	Niaprazine