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SKF-89,145

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
SKF-89,145
Identifiers
  • 4-(6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridin-4-yl)benzene-1,2-diol
CAS Number
PubChemCID
ChemSpider
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC14H15NO2S
Molar mass261.34 g·mol−1
3D model (JSmol)
  • Oc1ccc(cc1O)C2CN(C)Cc3sccc23
  • InChI=1S/C14H15NO2S/c1-15-7-11(10-4-5-18-14(10)8-15)9-2-3-12(16)13(17)6-9/h2-6,11,16-17H,7-8H2,1H3
  • Key:SYHALWYYSDMSLE-UHFFFAOYSA-N
  (verify)

SKF-89,145 is a drug which acts as adopamine agonist selective for theD1 subtype. TheN-desmethyl derivative SKF-89,626 is also a selective D1 agonist with similar potency and selectivity to SKF 89,145.[1]

References

[edit]
  1. ^O'Boyle KM, Waddington JL (December 1987). "New substituted 1-phenyl-3-benzazepine analogues of SK&F 38393 and N-methyl-thienopyridine analogues of dihydroxynomifensine with selective affinity for the D-1 dopamine receptor in human post-mortem brain".Neuropharmacology.26 (12):1807–10.doi:10.1016/0028-3908(87)90139-0.PMID 3501846.S2CID 34415106.
D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists
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