Sialic acid-binding Ig-like lectin 10 is aprotein that in humans is encoded by theSIGLEC10gene.[5][6] Siglec-G is often referred to as the murine paralog of human Siglec-10[7]
Like most but not all other Siglecs, Siglec-10 bears an ITIM (Immunoreceptor tyrosine-based inhibitory motif) within its cytoplasmic domain. Siglec-10 is a ligand forCD52, the target of the therapeutic monoclonal antibodyAlemtuzumab.[8] It is also reported to bind toVascular adhesion protein 1 (VAP-1) and to the co-stimulatory moleculeCD24 also known as HSA (Heat-stable antigen).
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM][6]
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Nagano T, Yoneda T, Hatanaka Y, et al. (2002). "Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone".Nat. Cell Biol.4 (7):495–501.doi:10.1038/ncb808.PMID12055638.S2CID4795393.
Kitzig F, Martinez-Barriocanal A, López-Botet M, Sayós J (2002). "Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1".Biochem. Biophys. Res. Commun.296 (2):355–62.Bibcode:2002BBRC..296..355K.doi:10.1016/S0006-291X(02)00885-9.PMID12163025.
