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SGK3

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
SGK3
Identifiers
AliasesSGK3, CISK, SGK2, SGKL, serum/glucocorticoid regulated kinase family member 3
External IDsOMIM:607591;MGI:2182368;HomoloGene:56582;GeneCards:SGK3;OMA:SGK3 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for SGK3
Genomic location for SGK3
Band8q13.1Start66,712,734bp[1]
End66,862,022bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for SGK3
Genomic location for SGK3
Band1 A2|1 2.08 cMStart9,868,332bp[2]
End9,971,070bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • retinal pigment epithelium

  • corpus callosum

  • inferior ganglion of vagus nerve

  • mucosa of ileum

  • subthalamic nucleus

  • skin of arm

  • pars reticulata

  • jejunal mucosa

  • medulla oblongata

  • skin of hip
Top expressed in
  • vestibular membrane of cochlear duct

  • retinal pigment epithelium

  • Epithelium of choroid plexus

  • molar

  • gastrula

  • granulocyte

  • hair follicle

  • endothelial cell of lymphatic vessel

  • cornea

  • stria vascularis
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23678

170755

Ensembl

ENSG00000104205

ENSMUSG00000025915

UniProt

Q96BR1

Q9ERE3

RefSeq (mRNA)

NM_170709
NM_001033578
NM_013257

NM_001037759
NM_133220
NM_177547

RefSeq (protein)

NP_001191102
NP_001028750
NP_037389
NP_733827

NP_001032848
NP_573483
NP_808215

Location (UCSC)Chr 8: 66.71 – 66.86 MbChr 1: 9.87 – 9.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase Sgk3 is anenzyme that in humans is encoded by theSGK3gene.[5][6][7]

Function

[edit]

This gene is a member of theserine/threonine protein kinase family and encodes aphosphoprotein with aPX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation ofpotassium andchloride channels. Alternatetranscriptional splice variants, encoding differentisoforms, have been characterized.[7]

Inmelanocytic cells SGK3 gene expression may be regulated byMITF.[8]

Interactions

[edit]

SGK3 has been shown tointeract withGSK3B.[9]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000104205Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000025915Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Dai F, Yu L, He H, Zhao Y, Yang J, Zhang X, Zhao S (February 2000). "Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1".Genomics.62 (1):95–7.doi:10.1006/geno.1999.5969.PMID 10585774.
  6. ^Kobayashi T, Deak M, Morrice N, Cohen P (January 2000)."Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase".Biochem J. 344 Pt 1 (Pt 1):189–97.doi:10.1042/0264-6021:3440189.PMC 1220630.PMID 10548550.
  7. ^ab"Entrez Gene: SGK3 serum/glucocorticoid regulated kinase family, member 3".
  8. ^Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008)."Novel MITF targets identified using a two-step DNA microarray strategy".Pigment Cell Melanoma Res.21 (6):665–76.doi:10.1111/j.1755-148X.2008.00505.x.PMID 19067971.S2CID 24698373.
  9. ^Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S (May 2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction".Biochem. Biophys. Res. Commun.293 (4):1191–6.Bibcode:2002BBRC..293.1191D.doi:10.1016/S0006-291X(02)00349-2.PMID 12054501.

Further reading

[edit]
PDB gallery
  • 1xte: crystal structure of CISK-PX domain
    1xte: crystal structure of CISK-PX domain
  • 1xtn: crystal structure of CISK-PX domain with sulfates
    1xtn: crystal structure of CISK-PX domain with sulfates
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
Activity
Regulation
Classification
Kinetics
Types
Portal:


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