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SEMA4D

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From Wikipedia, the free encyclopedia

Protein found in Homo sapiens

SEMA4D

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
1OLZ,3OL2

Identifiers

Aliases

SEMA4D, C9orf164, CD100, M-sema-G, SEMAJ, coll-4, semaphorin 4D, COLL4, A8, GR3, BB18

External IDs

OMIM:601866;MGI:109244;HomoloGene:21282;GeneCards:SEMA4D;OMA:SEMA4D - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9q22.2	Start	89,360,787bp^[1]
Band	9q22.2	End	89,498,130bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13\|13 A5	Start	51,685,529bp^[2]
Band	13\|13 A5	End	51,793,747bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

C1 segment

granulocyte

corpus callosum

blood

monocyte

inferior ganglion of vagus nerve

lymph node

muscle of thigh

internal globus pallidus

substantia nigra

Top expressed in

granulocyte

muscle of thigh

mesenteric lymph nodes

thymus

lumbar subsegment of spinal cord

cumulus cell

tibiofemoral joint

blood

dentate gyrus of hippocampal formation granule cell

spleen

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	signaling receptor binding transmembrane signaling receptor activity protein binding semaphorin receptor binding neuropilin binding identical protein binding signaling receptor activity chemorepellent activity
Cellular component	integral component of membrane integral component of plasma membrane membrane plasma membrane extracellular space
Biological process	regulation of dendrite morphogenesis negative regulation of apoptotic process positive regulation of phosphatidylinositol 3-kinase signaling multicellular organism development leukocyte aggregation nervous system development negative regulation of cell adhesion positive regulation of peptidyl-tyrosine phosphorylation positive regulation of axonogenesis semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis regulation of cell projection organization negative regulation of osteoblast differentiation positive regulation of collateral sprouting regulation of cell shape negative regulation of peptidyl-tyrosine phosphorylation cell differentiation positive regulation of protein phosphorylation semaphorin-plexin signaling pathway cell adhesion immune response ossification involved in bone maturation positive regulation of cell migration negative regulation of transcription by RNA polymerase II positive regulation of GTPase activity negative regulation of alkaline phosphatase activity negative chemotaxis neural crest cell migration negative regulation of axon extension involved in axon guidance positive regulation of inhibitory synapse assembly
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


10507


20354

Ensembl


ENSG00000187764


ENSMUSG00000021451

UniProt


Q92854


O09126

RefSeq (mRNA)

NM_001142287 NM_006378 NM_182635 NM_001371194 NM_001371195
NM_001371196 NM_001371197 NM_001371198 NM_001371199 NM_001371200 NM_001371201 NM_001371202


NM_001281880 NM_013660

RefSeq (protein)

NP_001135759 NP_006369 NP_001358123 NP_001358124 NP_001358125
NP_001358126 NP_001358127 NP_001358128 NP_001358129 NP_001358130 NP_001358131

NP_001268809 NP_038688 NP_001365242 NP_001365243 NP_001365246
NP_001365247 NP_001365248 NP_001365249 NP_001365251 NP_001365252 NP_001365253 NP_001365244 NP_001365245 NP_001365250 NP_001365254

Location (UCSC)

Chr 9: 89.36 – 89.5 Mb

Chr 13: 51.69 – 51.79 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Semaphorin-4D (SEMA4D) also known asCluster ofDifferentiation100 (CD100), is aprotein of thesemaphorin family that in humans is encoded by theSEMA4Dgene.^[5]

Function

[edit]

Semaphorin 4D (Sema 4D) is anaxon guidance molecule which is secreted byoligodendrocytes and inducesgrowth cone collapse in thecentral nervous system. By bindingplexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system.^[6]

In the immune system, CD100 bindsCD72 to activateB cells anddendritic cells, though much about this interaction is still under investigation.^[7]^[8]

Duringskin damage repairs, SEMA4D interacts withPlexin B2 onGamma delta T cells to play a role in the healing process.^[9]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000187764 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000021451 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D".
^Ito Y, Oinuma I, Katoh H, Kaibuchi K, Negishi M (July 2006)."Sema4D/plexin-B1 activates GSK-3β through R-Ras GAP activity, inducing growth cone collapse".EMBO Reports.7 (7):704–9.doi:10.1038/sj.embor.7400737.PMC 1500830.PMID 16799460.
^Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T, Matsumoto M, Yoshida K, Yakura H, Pan C, Parnes JR, Kikutani H (November 2000)."Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling".Immunity.13 (5):621–31.doi:10.1016/S1074-7613(00)00062-5.PMID 11114375.
^Ishida I, Kumanogoh A, Suzuki K, Akahani S, Noda K, Kikutani H (August 2003)."Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses".Int. Immunol.15 (8):1027–34.doi:10.1093/intimm/dxg098.PMID 12882840.
^Deborah A. Witherden, Megumi Watanabe, Olivia Garijo, Stephanie E. Rieder, Gor Sarkisyan, Shane J.F. Cronin, Petra Verdino, Ian A. Wilson, Atsushi Kumanogoh, Hitoshi Kikutani, Luc Teyton, Wolfgang H. Fischer, Wendy L. Havran (August 2012)."The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function".Immunity.37 (2):314–25.doi:10.1016/j.immuni.2012.05.026.PMC 3430606.PMID 22902232.

External links

[edit]

SEMA4D+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

v t e PDB gallery
1olz: THE LIGAND-BINDING FACE OF THE SEMAPHORINS REVEALED BY THE HIGH RESOLUTION CRYSTAL STRUCTURE OF SEMA4D

v t e Proteins:clusters of differentiation (see alsolist of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 -CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 -CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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SEMA4D

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See also

References

Further reading

External links