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SB-366791

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
SB-366791
Identifiers
  • (E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide
CAS Number
PubChemCID
ChemSpider
UNII
ChEBI
ChEMBL
Chemical and physical data
FormulaC16H14ClNO2
Molar mass287.74 g·mol−1
3D model (JSmol)
  • COC1=CC=CC(=C1)NC(=O)/C=C/C2=CC=C(C=C2)Cl
  • InChI=1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+
  • Key:RYAMDQKWNKKFHD-JXMROGBWSA-N

SB-366791 is a drug which acts as a potent and selective blocker of theTRPV1ion channel. It hasanalgesic effects in animal studies, and is used in research into pain and inflammation.[1][2][3]

See also

[edit]

References

[edit]
  1. ^Dell H (December 2003). "New compound fires up pain research".Drug Discovery Today.8 (23): 1053.doi:10.1016/s1359-6446(03)02928-3.PMID 14693457.
  2. ^Ma SX, Kim HC, Lee SY, Jang CG (December 2018). "TRPV1 modulates morphine self-administration via activation of the CaMKII-CREB pathway in the nucleus accumbens".Neurochemistry International.121:1–7.doi:10.1016/j.neuint.2018.10.009.PMID 30292787.S2CID 52929149.
  3. ^Uchytilova E, Spicarova D, Palecek J (April 2021)."Hypersensitivity Induced by Intrathecal Bradykinin Administration Is Enhanced by N-oleoyldopamine (OLDA) and Prevented by TRPV1 Antagonist".International Journal of Molecular Sciences.22 (7): 3712.doi:10.3390/ijms22073712.PMC 8038144.PMID 33918267.
TRPA
Activators
Blockers
TRPC
Activators
Blockers
TRPM
Activators
Blockers
TRPML
Activators
Blockers
TRPP
Activators
Blockers
TRPV
Activators
Blockers


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