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Zeta variant, also known aslineage P.2,^[a] is avariant ofSARS-CoV-2, the virus that causesCOVID-19. It was first detected in the state ofRio de Janeiro; it harbors the E484Kmutation, but not the N501Y and K417T mutations. It evolved independently in Rio de Janeiro without being directly related to theGamma variant from Manaus.^[1][2]

Under the simplified naming scheme proposed by theWorld Health Organization, P.2 was labeled "Zeta variant", and was considered a variant of interest (VOI), but not avariant of concern.^[3] A second wave was preceded in November 2020 by an increase in the prevalence of the Zeta variant among genetic sequences from São Paulo state, deposited into theGISAID database.^[4] As of July 2021, Zeta is no longer considered a variant of interest by the WHO.^[5]

The Zeta genome has 3amino acid mutations:E484K,D614G, and V1176F, all of which are found in thevirus'sspike protein code.^[6] According to theCenters for Disease Control and Prevention, F565L has been detected in some of the Zeta variant sequences, but not all.^[7]

• 
  Amino acid mutations of SARS-CoV-2 Zeta variant plotted on a genome map of SARS-CoV-2 with a focus on the spike.^[6]

• COVID-19 pandemic in Rio de Janeiro (state)
• Variants of SARS-CoV-2

• Articles with short description
• Short description matches Wikidata
• Use mdy dates from June 2021