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S42 (selective androgen receptor modulator)

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Pharmaceutical compound
S42 (selective androgen receptor modulator)
Identifiers
  • 1-[(8S,9S,13S,14S,17S)-4,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]ethanone
Chemical and physical data
FormulaC21H28O
Molar mass296.454 g·mol−1
3D model (JSmol)
  • C[C@]12CC[C@H]3[C@@H](CCc4c3cccc4C)[C@@H]1CC[C@@H]2C(=O)C
  • InChI=1S/C21H28O/c1-13-5-4-6-16-15(13)7-8-18-17(16)11-12-21(3)19(14(2)22)9-10-20(18)21/h4-6,17-20H,7-12H2,1-3H3/t17-,18-,19-,20+,21-/m1/s1
  • Key:QHOSKNZHWGWGMX-SSSFQFABSA-N

S42 is a fully synthetic steroidalselective androgen receptor modulator (SARM) developed for the treatment of muscle wasting in the elderly.[1][2][3][4]

See also

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References

[edit]
  1. ^US 8623909, Nawata H, Yanase T, Nakagawa T, "Prophylactic/therapeutic agents for lifestyle-related diseases.", issued 7 January 2014, assigned to Aska Pharmaceutical Co Ltd. 
  2. ^Muta Y, Tanaka T, Hamaguchi Y, Hamanoue N, Motonaga R, Tanabe M, et al. (March 2019)."Selective androgen receptor modulator, S42 has anabolic and anti-catabolic effects on cultured myotubes".Biochemistry and Biophysics Reports.17:177–181.doi:10.1016/j.bbrep.2019.01.006.PMC 6348734.PMID 30705972.
  3. ^Wen HC, Wilczek T, Neudörfl JM, Wagener F, Piper T, Thevis M, et al. (August 2024). "A comprehensive gas chromatography electron ionization high resolution mass spectrometry study of a new steroidal selective androgen receptor modulator (SARM) compound S42".Journal of Mass Spectrometry.59 (8) e5077.doi:10.1002/jms.5077.PMID 39102231.
  4. ^Wen HC, Wagener F, Piper T, Neudörfl J, Thevis M, Schäfer M (March 2025). "Investigations Into Structures of In Vitro-Derived Phase I Metabolites of a Novel 20-Keto-Steroid S42 by GC-EI HR MS Analysis and Chemical Synthesis".Drug Testing and Analysis.doi:10.1002/dta.3890.PMID 40159391.
ARTooltip Androgen receptor
Agonists
SARMsTooltip Selective androgen receptor modulator
Antagonists
GPRC6A
Agonists
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