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S1PR5

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

S1PR5

Identifiers

Aliases

S1PR5, EDG8, Edg-8, S1P5, SPPR-1, SPPR-2, sphingosine-1-phosphate receptor 5

External IDs

OMIM:605146;MGI:2150641;HomoloGene:11031;GeneCards:S1PR5;OMA:S1PR5 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.2	Start	10,512,742bp^[1]
Band	19p13.2	End	10,517,931bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 A3	Start	21,154,208bp^[2]
Band	9\|9 A3	End	21,159,739bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

granulocyte

C1 segment

internal globus pallidus

inferior ganglion of vagus nerve

corpus callosum

substantia nigra

skin of arm

subthalamic nucleus

blood

putamen

Top expressed in

lumbar subsegment of spinal cord

substantia nigra

motor neuron

deep cerebellar nuclei

conjunctival fornix

lateral geniculate nucleus

anterior horn of spinal cord

cornea

pontine nuclei

globus pallidus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	sphingosine-1-phosphate receptor activity G protein-coupled receptor activity signal transducer activity
Cellular component	integral component of membrane plasma membrane membrane
Biological process	regulation of neuron differentiation sphingosine-1-phosphate receptor signaling pathway signal transduction G protein-coupled receptor signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


53637


94226

Ensembl


ENSG00000180739


ENSMUSG00000045087

UniProt


Q9H228


Q91X56

RefSeq (mRNA)


NM_030760 NM_001166215


NM_053190

RefSeq (protein)


NP_001159687 NP_110387


NP_444420

Location (UCSC)

Chr 19: 10.51 – 10.52 Mb

Chr 9: 21.15 – 21.16 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Sphingosine-1-phosphate receptor 5 also known asS1PR5 is a humangene which encodes aG protein-coupled receptor which binds the lipid signaling moleculesphingosine 1-phosphate (S1P). Hence this receptor is also known asS1P₅.^[5]

Agonists

[edit]

A-971432^[6]
Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)^[7]

Evolution

[edit]

Paralogues for S1PR5 Gene

[edit]

Source:^[8]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000180739 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000045087 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: S1PR5 Sphingosine-1-phosphate receptor 5".
^Hobson AD, Harris CM, van der Kam EL, Turner SC, Abibi A, Aguirre AL, Bousquet P, Kebede T, Konopacki DB, Gintant G, Kim Y, Larson K, Maull JW, Moore NS, Shi D, Shrestha A, Tang X, Zhang P, Sarris KK (Nov 2015). "Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders".Journal of Medicinal Chemistry.58 (23):9154–70.doi:10.1021/acs.jmedchem.5b00928.PMID 26509640.
^Roberts E, Guerrero M, Urbano M, Rosen H (Jul 2013). "Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)".Expert Opin Ther Pat.23 (7):817–41.doi:10.1517/13543776.2013.783022.PMID 23541049.S2CID 24421259.
^"GeneCards®: The Human Gene Database".

External links

[edit]

"Lysophospholipid Receptors: S₁P₅".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Lysophospholipid+receptors at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)