Sphingosine-1-phosphate receptor 3 also known asS1PR3 is a humangene which encodes aG protein-coupled receptor which binds the lipid signaling moleculesphingosine 1-phosphate (S1P). Hence this receptor is also known asS1P3.[5]
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.[5]
Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]".Tanpakushitsu Kakusan Koso.47 (4 Suppl):496–502.PMID11915348.
Van Koppen CJ, Meyer Zu Heringdorf D, Zhang C, et al. (1996). "A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils".Mol. Pharmacol.49 (6):956–61.PMID8649355.
Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9".Biochem. Biophys. Res. Commun.227 (2):608–14.doi:10.1006/bbrc.1996.1553.PMID8878560.
Zhang Q, Peyruchaud O, French KJ, et al. (1999). "Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway".Blood.93 (9):2984–90.doi:10.1182/blood.V93.9.2984.PMID10216094.
Goetzl EJ, Dolezalova H, Kong Y, et al. (1999). "Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer".Cancer Res.59 (20):5370–5.PMID10537322.
Orlati S, Porcelli AM, Hrelia S, et al. (2000). "Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor".Arch. Biochem. Biophys.375 (1):69–77.doi:10.1006/abbi.1999.1589.PMID10683250.
"Lysophospholipid Receptors: S1P3".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2008-12-05.
