This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation.[5] It has also been shown to interact with Nogo-A (RTN4), an neurite outgrowth inhibitor.[6] S1PR2 is expressed in neuronal and vascular cells and is crucial for the migration and growth of developing and injured neuronal and vascular system.[7][8]
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"Lysophospholipid Receptors: S1P2".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2008-12-05.
