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| Clinical data | |
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| Trade names | Banzel, Inovelon |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a609001 |
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| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Bioavailability | 85% (under fed conditions);tmax = 4–6 hours |
| Protein binding | 34% |
| Metabolism | Carboxylesterase-mediated hydrolysis (CYP not involved) |
| Metabolites | Inactive |
| Eliminationhalf-life | 6–10 hours |
| Excretion | Urine (85%)[2] |
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| Chemical and physical data | |
| Formula | C10H8F2N4O |
| Molar mass | 238.198 g·mol−1 |
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Rufinamide is ananticonvulsant medication. It is used in combination with other medication and therapy to treatLennox–Gastaut syndrome[3] and various otherseizure disorders. Rufinamide, atriazole derivative, was developed in 2004 byNovartis Pharma, AG, and is manufactured byEisai.
Rufinamide was approved by the USFood and Drug Administration (FDA) in November 2008, as adjunctive treatment of seizures associated with Lennox-Gastaut syndrome in children four years and older and adults. Its official FDA-approved labeling does not mention use in the treatment of partial seizures inasmuch as clinical trials submitted to the FDA were marginal. However, several recent clinical trials suggest that the drug has efficacy for partial seizures[4] It is marketed under the brand nameBanzel.[5] It is also marketed in the European Union under the brand nameInovelon.[6] It is available as ageneric medication.[7]
Themechanism of action of rufinamide is not fully understood. There is some evidence that rufinamide can modulate the gating ofvoltage-gated sodium channels,[8][9] a common target for antiepileptic drugs.[10] A recent study indicates subtle effects on the voltage-dependence of gating and the time course of inactivation in some sodium channel isoforms that could reduce neuronal excitability.[11] However, this action cannot explain the unique spectrum of activity of rufinamide.
