Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

Rosonabant

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Rosonabant
Clinical data
ATC code
  • None
Identifiers
  • (±)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(1-piperidinyl)-4,5-dihydro-1H-pyrazole-3-carboxamide
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC21H21Cl3N4O
Molar mass451.78 g·mol−1
3D model (JSmol)
  • O=C(NN1CCCCC1)\C4=N\N(c2ccc(Cl)cc2Cl)C(c3ccc(Cl)cc3)C4
  • InChI=1S/C21H21Cl3N4O/c22-15-6-4-14(5-7-15)20-13-18(21(29)26-27-10-2-1-3-11-27)25-28(20)19-9-8-16(23)12-17(19)24/h4-9,12,20H,1-3,10-11,13H2,(H,26,29)
  • Key:WMMMJGKFKKBRQR-UHFFFAOYSA-N

Rosonabant (INN;E-6776) is adrug acting as aCB1 receptorantagonist/inverse agonist that was under investigation byEsteve as anappetite suppressant for the treatment ofobesity.[1][2] Development of the drug forclinical use was apparently halted shortly after the related CB1 antagonistrimonabant was discontinued in November 2008,[when?] due to the reports of severepsychiatricadverse effects such asanxiety,depression, andsuicidal ideation associated with it and with similarly acting agents.[3][4][5]

See also

[edit]

References

[edit]
  1. ^Janero DR,Makriyannis A (March 2009). "Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis".Expert Opinion on Emerging Drugs.14 (1):43–65.doi:10.1517/14728210902736568.PMID 19249987.S2CID 74250986.
  2. ^Vickers SP, Cheetham SC (2007)."Preclinical Developments in Antiobesity Drugs". In Kirkham TC, Cooper SJ (eds.).Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs. Academic Press. p. 325.ISBN 978-0-12-370633-1. Retrieved12 May 2012.
  3. ^Heal DJ, Gosden J, Smith SL (December 2009)."Regulatory challenges for new drugs to treat obesity and comorbid metabolic disorders".British Journal of Clinical Pharmacology.68 (6):861–874.doi:10.1111/j.1365-2125.2009.03549.x.PMC 2810797.PMID 20002080.
  4. ^Lee HK, Choi EB, Pak CS (2009)."The current status and future perspectives of studies of cannabinoid receptor 1 antagonists as anti-obesity agents".Current Topics in Medicinal Chemistry.9 (6):482–503.doi:10.2174/156802609788897844.PMID 19689362. Archived fromthe original on 2013-05-22.
  5. ^Moreira FA, Crippa JA (June 2009)."The psychiatric side-effects of rimonabant".Revista Brasileira de Psiquiatria.31 (2):145–153.doi:10.1590/S1516-44462009000200012.PMID 19578688.
Stimulants
Amphetamines and
phenethylamines
Adrenergic agonists
Other
Cannabinoid
antagonists
GLP-1,GIP,and / or
glucagon agonists
DACRAs
5-HT2C
receptor agonists
Absorption inhibitors
Uncouplers
Others
Phytocannabinoids
(comparison)
Cannabibutols
Cannabichromenes
Cannabicyclols
Cannabidiols
Cannabielsoins
Cannabigerols
Cannabiphorols
Cannabinols
Cannabitriols
Cannabivarins
Delta-3-tetrahydrocannabinols
Delta-4-tetrahydrocannabinols
Delta-7-tetrahydrocannabinols
Delta-8-tetrahydrocannabinols
Delta-9-tetrahydrocannabinols
Delta-10-Tetrahydrocannabinols
Delta-11-Tetrahydrocannabinols
Miscellaneous cannabinoids
Active metabolites
Endocannabinoids
Synthetic
cannabinoid
receptor
agonists /
neocannabinoids
Classical cannabinoids
(dibenzopyrans)
Non-classical
cannabinoids
Adamantoylindoles
Benzimidazoles
Benzoylindoles
Cyclohexylphenols
Eicosanoids
Indazole-3-
carboxamides
Indole-3-carboxamides
Indole-3-carboxylates
Naphthoylindazoles
Naphthoylindoles
Naphthoylpyrroles
Naphthylmethylindenes
Naphthylmethylindoles
Phenylacetylindoles
Pyrazolecarboxamides
Tetramethylcyclo-
propanoylindazoles
Tetramethylcyclo-
propanoylindoles
Others
AllostericCBRTooltip Cannabinoid receptorligands
Endocannabinoid
enhancers
(inactivation inhibitors)
Anticannabinoids
(antagonists/inverse
agonists/antibodies)
Receptor
(ligands)
CB1Tooltip Cannabinoid receptor type 1
Agonists
(abridged,
full list)
Inverse agonists
Antagonists
CB2Tooltip Cannabinoid receptor type 2
Agonists
Antagonists
NAGly
(GPR18)
Agonists
Antagonists
GPR55
Agonists
Antagonists
GPR119
Agonists
Transporter
(modulators)
eCBTsTooltip Endocannabinoid transporter
Enzyme
(modulators)
FAAHTooltip Fatty acid amide hydrolase
MAGL
ABHD6
ABHD12
Others
  • Others:2-PG(directly potentiates activity of 2-AG at CB1 receptor)
  • ARN-272(FAAH-like anandamide transporter inhibitor)
See also
Receptor/signaling modulators
Cannabinoids (cannabinoids by structure)
Stub icon

Thiscannabinoid related article is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Rosonabant&oldid=1292432432"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2025 Movatter.jp