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| ECHA InfoCard | 100.162.290 |
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| Formula | C16H12Cl2N2O |
| Molar mass | 319.19 g·mol−1 |
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Ro5-4864[1] (4'-chlorodiazepam) is a drug which is abenzodiazepine derivative ofdiazepam.[2] However unlike most benzodiazepine derivatives, Ro5-4864 lacks affinity forGABAAreceptors and lacks typical benzodiazepine effects,[3] instead beingsedative yet alsoconvulsant andanxiogenic in effects.[4][5][6][7] Ro5-4864 was found to be a potent ligand for the "peripheral benzodiazepine receptor",[8] later renamed tomitochondrial translocator protein 18kDa (TSPO). Despite its convulsant effects, at lower doses Ro5-4864 has proved to beneuroprotective and has become widely used for research into the role of the TSPO protein inneurotoxicity.[9][10][11][12][13][14]In vitro studies androdent models also suggest the possibility ofanalgesic,[15]antidepressant,[16] cardioprotective,[17] and anti-cancer effects.[18][19][20][21][non-primary source needed]
