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| Formula | C21H27N3 |
| Molar mass | 321.468 g·mol−1 |
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Rimcazole is anantagonist[1] of thesigma receptor[2] as well as adopamine reuptake inhibitor.[3] Sigma receptors are thought to be involved in the drugpsychosis that can be induced by some drugs such asphencyclidine andcocaine, and rimcazole was originally researched as a potentialantipsychotic with a different mechanism of action to traditional antipsychotic drugs, although common withbutyrophenone antipsychotics such ashaloperidol. Trials proved inconclusive and rimcazole was not pursued for this application, but other sigma antagonists continue to be researched for a variety of potential applications.[4] Rimcazole has been shown to reduce the effects of cocaine,[5] and analogues of rimcazole have been shown to be highly effective at blocking theconvulsions caused by cocaineoverdose in animal models.[6]Isothiocyanatederivatives of rimcazole acting as irreversibledopamine transporter (DAT) blockers have been developed.[3]
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