Theantidepressanttianeptine was once claimed to be a(selective)serotonin reuptake enhancer (SRE or SSRE), but the role of serotonin reuptake in its mechanism is doubtful. Tianeptine has no affinity for theserotonin transporter, neither increases nor decreases extracellular levels of serotonin incortico-limbic structures of conscious rats, and it didn't show any other long-term effect on the serotonin pathway.[1] Ultimately, tianeptine was determined to be a selective mu opioid receptor agonist.
^Bessho, Tomoko; Takashina, Ken; Eguchi, Junichi; Komatsu, Teiko; Saito, Ken-Ichi (July 2008). "MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats".J Neural Transm.115 (7):1019–25.doi:10.1007/s00702-008-0053-4.PMID18461272.S2CID20201642.
^Zhao G, Qin GW, Wang J, Chu WJ, Guo LH (2010). "Functional activation of monoamine transporters by luteolin and apigenin isolated from the fruit of Perilla frutescens (L.) Britt".Neurochem. Int.56 (1):168–76.doi:10.1016/j.neuint.2009.09.015.PMID19815045.S2CID24753206.
^Zhang J, Liu X, Lei X, et al. (2010). "Discovery and synthesis of novel luteolin derivatives as DAT agonists".Bioorg. Med. Chem.18 (22):7842–8.doi:10.1016/j.bmc.2010.09.049.PMID20971650.
