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Retinoid X receptor beta

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
RXRB
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1H9U,1UHL,5HJP,5I4V

Identifiers
AliasesRXRB, DAUDI6, H-2RIIBP, NR2B2, RCoR-1, Retinoid X receptor beta, RXRbeta, RXR-beta
External IDsOMIM:180246;MGI:98215;HomoloGene:7923;GeneCards:RXRB;OMA:RXRB - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for RXRB
Genomic location for RXRB
Band6p21.32Start33,193,588bp[1]
End33,200,665bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for RXRB
Genomic location for RXRB
Band17 B1|17 17.98 cMStart34,250,786bp[2]
End34,257,373bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of thyroid gland

  • granulocyte

  • gastric mucosa

  • left lobe of thyroid gland

  • right coronary artery

  • right uterine tube

  • body of uterus

  • right ovary

  • pituitary gland

  • canal of the cervix
Top expressed in
  • Ileal epithelium

  • internal carotid artery

  • external carotid artery

  • granulocyte

  • renal corpuscle

  • muscle of thigh

  • ankle

  • crypt of lieberkuhn of small intestine

  • motor neuron

  • fossa
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6257

20182

Ensembl
ENSG00000235712
ENSG00000231321
ENSG00000227322
ENSG00000204231
ENSG00000206289

ENSG00000228333

ENSMUSG00000039656

UniProt

P28702
Q5STP9

P28704

RefSeq (mRNA)

NM_001270401
NM_001291989
NM_021976

NM_001205214
NM_001205215
NM_001205216
NM_011306

RefSeq (protein)

NP_001257330
NP_001278918
NP_068811
NP_068811.1

NP_001192143
NP_001192144
NP_001192145
NP_035436

Location (UCSC)Chr 6: 33.19 – 33.2 MbChr 17: 34.25 – 34.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Retinoid X receptor beta (RXR-beta), also known asNR2B2 (nuclear receptor subfamily 2, group B, member 2) is anuclear receptor that in humans is encoded by theRXRB gene.[5][6]

This gene encodes a member of theretinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects ofretinoic acid (RA). This receptor forms heterodimers with theretinoic acid,thyroid hormone, andvitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Analternatively spliced transcript variant has been described, but its full length sequence has not been determined.[6]

Interactive pathway map

[edit]

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

  1. ^The interactive pathway map can be edited at WikiPathways:"VitaminDSynthesis_WP1531".

See also

[edit]

References

[edit]
  1. ^abcENSG00000231321, ENSG00000227322, ENSG00000204231, ENSG00000206289, ENSG00000228333 GRCh38: Ensembl release 89: ENSG00000235712, ENSG00000231321, ENSG00000227322, ENSG00000204231, ENSG00000206289, ENSG00000228333Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000039656Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Fitzgibbon J, Gillett GT, Woodward KJ, Boyle JM, Wolfe J, Povey S (Jul 1993). "Mapping of RXRB to human chromosome 6p21.3".Annals of Human Genetics.57 (Pt 3):203–9.doi:10.1111/j.1469-1809.1993.tb01596.x.PMID 8257090.S2CID 26964941.
  6. ^ab"Entrez Gene: RXRB retinoid X receptor, beta".

Further reading

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

PDB gallery
  • 1by4: STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA
    1by4: STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA
  • 1dsz: STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1
    1dsz: STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1
  • 1h9u: THE STRUCTURE OF THE HUMAN RETINOID-X-RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH THE SPECIFIC SYNTHETIC AGONIST LG100268
    1h9u: THE STRUCTURE OF THE HUMAN RETINOID-X-RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH THE SPECIFIC SYNTHETIC AGONIST LG100268
  • 1r0n: Crystal Structure of Heterodimeric Ecdsyone receptor DNA binding complex
    1r0n: Crystal Structure of Heterodimeric Ecdsyone receptor DNA binding complex
  • 1rxr: HIGH RESOLUTION SOLUTION STRUCTURE OF THE RETINOID X RECEPTOR DNA BINDING DOMAIN, NMR, 20 STRUCTURE
    1rxr: HIGH RESOLUTION SOLUTION STRUCTURE OF THE RETINOID X RECEPTOR DNA BINDING DOMAIN, NMR, 20 STRUCTURE
  • 1uhl: Crystal structure of the LXRalfa-RXRbeta LBD heterodimer
    1uhl: Crystal structure of the LXRalfa-RXRbeta LBD heterodimer
  • 2nll: RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA
    2nll: RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA
(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous
RARTooltip Retinoic acid receptor
RXRTooltip Retinoid X receptor


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