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Relaxin/insulin-like family peptide receptor 2

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

RXFP2

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
2M96

Identifiers

Aliases

RXFP2, GPR106, GREAT, INSL3R, LGR8, LGR8.1, RXFPR2, Relaxin/insulin-like family peptide receptor 2, relaxin/insulin like family peptide receptor 2, relaxin family peptide receptor 2

External IDs

OMIM:606655;MGI:2153463;HomoloGene:15402;GeneCards:RXFP2;OMA:RXFP2 - orthologs

Gene location (Human)

Chr.	Chromosome 13 (human)^[1]

Band	13q13.1	Start	31,739,526bp^[1]
Band	13q13.1	End	31,803,389bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5 G3\|5 89.23 cM	Start	149,942,140bp^[2]
Band	5 G3\|5 89.23 cM	End	150,005,649bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

monocyte

granulocyte

gonad

left uterine tube

blood

smooth muscle tissue

right adrenal cortex

left adrenal gland

left adrenal cortex

Top expressed in

mesothelium

spermatocyte

mesothelium of peritoneum

spermatid

seminiferous tubule

embryo

embryo

vas deferens

genital tubercle

abdominal wall

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein-hormone receptor activity signal transducer activity G protein-coupled receptor activity peptide hormone binding G protein-coupled peptide receptor activity
Cellular component	integral component of membrane membrane plasma membrane intracellular anatomical structure integral component of plasma membrane
Biological process	male gonad development negative regulation of apoptotic process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway oocyte maturation signal transduction negative regulation of cell population proliferation adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway positive regulation of cAMP-mediated signaling activation of adenylate cyclase activity hormone-mediated signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


122042


140498

Ensembl


ENSG00000133105


ENSMUSG00000053368

UniProt


Q8WXD0


Q91ZZ5

RefSeq (mRNA)


NM_001166058 NM_130806


NM_001289564 NM_001289566 NM_080468

RefSeq (protein)


NP_001159530 NP_570718


NP_001276493 NP_001276495 NP_536716

Location (UCSC)

Chr 13: 31.74 – 31.8 Mb

Chr 5: 149.94 – 150.01 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Relaxin/insulin-like family peptide receptor 2, also known asRXFP2, is a humanG-protein coupled receptor.^[5]

The receptors forglycoprotein hormones such asfollicle-stimulating hormone (FSH; see MIM 136530) andthyroid-stimulating hormone (TSH; see MIM 188540) areG protein-coupled, 7-transmembrane receptors (GPCRs) with large N-terminal extracellular domains.Leucine-rich repeat (LRR)-containing GPCRs (LGRs) form a subgroup of the GPCR superfamily. [supplied by OMIM].^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000133105 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000053368 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^b"Entrez Gene: RXFP2 relaxin/insulin-like family peptide receptor 2".

External links

[edit]

"Relaxin Family Peptide Receptors: RXFP2".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2008-12-09.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)