Studies have shown that rebamipide can fight the damaging effects ofNSAIDs on theGIT mucosa,[5] and more recently, the small intestine, but not for naproxen-induced gastric damage.[6]
Rebamipide is used in a number of Asian countries includingJapan (marketed as Mucosta),South Korea,China[7] andIndia (where it is marketed under the trade name Rebagen). It is also approved inRussia under the brand name Rebagit.[8]
Rebamipide increases gastric mucosalprostaglandin E2, protects gastric mucosa, thereby suppresses gastric mucosal damage and increases gastric mucus secretion and gastric mucosal blood flow, to improve hemodynamic impairment, suppress inflammation and repair the gastric mucosa. It is usually used to treat gastric ulcer and improve gastric mucosal lesion (erosion, bleeding, redness and edema) in acute gastritis and acute exacerbation period of chronic gastritis.
^Arakawa T, Kobayashi K, Yoshikawa T, Tarnawski A (September 1998). "Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing".Digestive Diseases and Sciences.43 (9 Suppl):5S –13S.PMID9753220.
^Arakawa T, Watanabe T, Fukuda T, Yamasaki K, Kobayashi K (November 1995). "Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine".Digestive Diseases and Sciences.40 (11):2469–72.doi:10.1007/bf02063257.PMID7587834.S2CID22807270.
^Tarnawski AS, Chai J, Pai R, Chiou SK (February 2004). "Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: a key to its ulcer healing action?".Digestive Diseases and Sciences.49 (2):202–9.doi:10.1023/b:ddas.0000017439.60943.5c.PMID15104358.S2CID31756608.
^Zhang S, Qing Q, Bai Y, Mao H, Zhu W, Chen Q, Zhang Y, Chen Y (July 2013). "Rebamipide helps defend against nonsteroidal anti-inflammatory drugs induced gastroenteropathy: a systematic review and meta-analysis".Digestive Diseases and Sciences.58 (7):1991–2000.doi:10.1007/s10620-013-2606-0.PMID23456504.S2CID4887031.
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