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Raseglurant

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Raseglurant
Clinical data
ATC code
  • None
Identifiers
  • 2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC15H13FN2
Molar mass240.281 g·mol−1
3D model (JSmol)
  • Fc2cccc(C#Cc1nc(cc(c1N)C)C)c2
  • InChI=1S/C15H13FN2/c1-10-8-11(2)18-14(15(10)17)7-6-12-4-3-5-13(16)9-12/h3-5,8-9H,17H2,1-2H3
  • Key:MEDCLNYIYBERKO-UHFFFAOYSA-N

Raseglurant (INN; development codeADX-10059) is anegative allosteric modulator of themGlu5 receptor andderivative ofMPEP which was under development byAddex Therapeutics for the treatment ofmigraine,gastroesophageal reflux disease, anddental anxiety.[1][2][3] It reachedphase IIclinical trials for all of the aforementioned indications before being discontinued due to the observation of possible predictive signs ofhepatotoxicity in patients with long-term use.[3][4][5]

See also

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References

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  1. ^Célanire S, Duvey G, Poli S, Rocher JP (January 2012)."mGluR2 activators and mGluR5 blockers advancing in the clinic for major CNS disorders.".Annual Reports in Medicinal Chemistry. Vol. 47. Academic Press. pp. 71–88.ISBN 978-0-12-397214-9.
  2. ^"Don't Dodge the Dentist – Tips for Dealing with Dental Anxiety". Retrieved2017-04-05.
  3. ^abStein MB, Steckler T (30 July 2010).Behavioral Neurobiology of Anxiety and Its Treatment. Springer Science & Business Media. pp. 397–.ISBN 978-3-642-02912-7.
  4. ^Dominguez C (18 November 2010).Neurodegenerative Diseases. Springer Science & Business Media. pp. 120–.ISBN 978-3-642-16758-4.
  5. ^Shaheen NJ (25 March 2013).Benign and Neoplastic Conditions of the Esophagus, An Issue of Gastroenterology Clinics. Elsevier Health Sciences. pp. 119–.ISBN 978-1-4557-7175-2.

External links

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Group I
mGluR1Tooltip Metabotropic glutamate receptor 1
mGluR5Tooltip Metabotropic glutamate receptor 5
Group II
mGluR2Tooltip Metabotropic glutamate receptor 2
mGluR3Tooltip Metabotropic glutamate receptor 3
Group III
mGluR4Tooltip Metabotropic glutamate receptor 4
mGluR6Tooltip Metabotropic glutamate receptor 6
mGluR7Tooltip Metabotropic glutamate receptor 7
mGluR8Tooltip Metabotropic glutamate receptor 8


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