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| Names | |
|---|---|
| IUPAC name 11β,17β-Dihydroxy-6-methyl-17α-(prop-1-yn-1-yl)androsta-1,4,6-trien-3-one | |
| Systematic IUPAC name (1S,3aS,3bS,9aR,9bS,10S,11aS)-1,10-Dihydroxy-5,9a,11a-trimethyl-1-(prop-1-yn-1-yl)-1,2,3,3a,3b,9a,9b,10,11,11a-decahydro-7H-cyclopenta[a]phenanthren-7-one | |
| Identifiers | |
3D model (JSmol) | |
| ChemSpider | |
| UNII | |
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| |
| Properties | |
| C23H28O3 | |
| Molar mass | 352.474 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
RU-28362 is asyntheticandrostaneglucocorticoid that was developed byRoussel Uclaf. It is aselectiveagonist of theglucocorticoid receptor (corticoid type II receptor), but not of themineralocorticoid receptor (corticoid type I receptor).[1][2]
A similar compound isdexamethasone that also selectively binds to the glucocorticoid receptor with high affinity. This is in contrast to the natural steroid hormonescortisol orcorticosterone, which bind to both of thecorticosteroid receptors, though they bind to the mineralocorticoid receptor with greater affinity.[3]
