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| Other names | RU28251; 4,α-Methylene-N,N-dipropyltryptamine; 4,α-Methylene-DPT |
| Drug class | Dopamine receptor agonist;D2-like receptoragonist;Prolactin inhibitor |
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| Chemical and physical data | |
| Formula | C17H24N2 |
| Molar mass | 256.393 g·mol−1 |
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RU-28251, also known as4,α-methylene-N,N-dipropyltryptamine (4,α-methylene-DPT), is atricyclicdopamine receptor agonist of thesimplified or partial ergoline family.[1][2][3][4][5] It is aselectiveD2-like receptoragonist.[4] The drug inhibitsprolactinsecretion in animals.[4] RU-28251 was first described in the literature by 1978.[2][6]
Some simpler derivatives of the ergot-type compounds also demonstrate significant DA-like activity. Such compounds include the ergoline fragment 25 (RU 28251) (Euvrard et al., 1981), which has been claimed (Bach and Kornfeld, 1978) to have OA-like properties, e.g., inhibition of prolactin secretion and displacement of OA from binding sites.
Table 1. Selective ligands of each dopamine receptor [...] D-2 [...] RU-28251 [...] 3.3.3 RU-28251 RU-28251, a partial ergoline containing a tricyclic ergoline ring (Fig. 5), was both a potent inhibitor of [3H]spiroperidol binding and an inhibitor of prolactin secretion (Bach et al. 1980; Euvrard et al. 1981). In addition, this agent caused contralateral rotation in lesioned rats (Bach et al. 1980). RU-28251, however, did not alter striatal adenylate cyclase activity (Euvrard et al. 1981). As with the other D-2 agonists, replacement of the n-propyl with a methyl or hydrogen resulted in decreased agonist activity.
{{cite book}}:|journal= ignored (help)Another ergoline analogue, RU 28251 (44), is a potent agonist in the Ungerstedt rotation model.102
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