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| Formula | C24H25ClN2O |
| Molar mass | 392.93 g·mol−1 |
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3β-(4-Methylphenyl)-2β-[3-(4-chlorophenyl)isoxazol-5-yl]tropane (RTI-4229-371) is aphenyltropane derived drug which acts as a potent and selectivedopamine reuptake inhibitorin vitro, yet unusually for this class of compound, both RTI-371 and the closely related compoundRTI-370 failed to producelocomotor stimulation in mice. In addition to this, in drug substitution tests RTI-370 weakly generalized to cocaine whereas RTI-371 did not generalize at all.
This phenomenon has also been observed for other dopamine reuptake inhibitors from other classes. It may be caused by lack ofBBB penetration, or interactions at alternative receptor sites.[1][2]
