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| Formula | C18H24INO2 |
| Molar mass | 413.299 g·mol−1 |
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(–)-2β-Carboisopropoxy-3β-(4-iodophenyl)tropane (RTI-4229-121,IPCIT) is astimulant drug used in scientific research, which was developed in the early 1990s.[1] RTI-121 is aphenyltropane based, highly selectivedopamine reuptake inhibitor[2] and is derived frommethylecgonidine. RTI-121 is a potent and long-lasting stimulant, producing stimulant effects for more than 10 hours after a single dose in mice[3] which would limit its potential uses in humans, as it might have significantabuse potential if used outside a medical setting. However RTI-121 occupies the dopamine transporter more slowly thancocaine, and so might have lower abuse potential than cocaine itself.[4]
RTI-121 is mainly used in scientific research into thedopamine reuptake transporter. It is more selective for the dopamine transporter than other DAT radioligands such asβ-CIT, and so has less nonspecific binding and produces "cleaner" images.[5][6] Variousradiolabelled forms of RTI-121 (with different radioactiveisotopes ofiodine used depending on the application) are used in both humans and animals to map the distribution ofdopamine transporters in thebrain.[7][8]
RTI-121 not specified as controlled substance in any country as of 2007. Some jurisdictions such as the United States, Australia, and New Zealand, however, might however consider RTI-121 to be acontrolled substance analogue of cocaine on the grounds of its related chemical structure.
