RFX4
Identifiers
Aliases	RFX4, NYD-SP10, regulatory factor X4
External IDs	OMIM:603958;MGI:1918387;HomoloGene:31119;GeneCards:RFX4;OMA:RFX4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.3 Start 106,583,004bp[1] End 106,762,803bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 84,591,926bp[2] End 84,742,402bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis external globus pallidus ventricular zone internal globus pallidus sperm caudate nucleus amygdala nucleus accumbens superior vestibular nucleus Top expressed in lumbar subsegment of spinal cord spermatocyte spermatid suprachiasmatic nucleus Rostral migratory stream globus pallidus ventricular zone deep cerebellar nuclei seminiferous tubule dorsal tegmental nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific chromatin binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component nucleus Biological process regulation of transcription by RNA polymerase II forebrain development telencephalon development dorsal spinal cord development regulation of transcription, DNA-templated negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning cerebellar cortex morphogenesis midbrain development positive regulation of transcription by RNA polymerase II regulation of protein processing transcription, DNA-templated transcription by RNA polymerase II cilium assembly Sources:Amigo /QuickGO
Orthologs Species Human Mouse Entrez 5992 71137 Ensembl ENSG00000111783 ENSMUSG00000020037 UniProt Q33E94 Q7TNK1 RefSeq (mRNA) NM_213594 NM_001206691 NM_002920 NM_032491 NM_001024918 NM_027689 RefSeq (protein) NP_001193620 NP_115880 NP_998759 NP_001020089 NP_081965 Location (UCSC) Chr 12: 106.58 – 106.76 Mb Chr 10: 84.59 – 84.74 Mb PubMed search [3] [4]
Wikidata
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Transcription factor RFX4 is aprotein that in humans is encoded by theRFX4gene.^[5][6][7]

This gene is a member of the regulatory factor X gene family, which encodestranscription factors that contain a highly conserved winged helix DNAbinding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptionalrepressor rather than a transcriptional activator. Three transcript variants encoding differentisoforms have been described for this gene.^[7]

RFX4 has been implicated in neural-lineage specification and in glioblastoma cell-state control: pooled transcription-factor overexpression with single-cell RNA-seq identified RFX4 as sufficient to induce neural progenitor–like programs from human pluripotent stem cells that differentiate toward CNS neuron and glia lineages,^[8] and in glioblastoma, RFX4 was reported as an orchestrator of growth and differentiation in diffusely invading tumor cells, where perturbation redistributed invasion routes and extended survival in xenografts.^[9]

• RFX4+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

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