Protein-coding gene in the species Homo sapiens
Transcription factor RFX3 is aprotein that in humans is encoded by theRFX3 gene .[ 5] [ 6]
This gene is a member of the regulatory factor X gene family, which encodestranscription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is atranscriptional activator that can bindDNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding differentisoforms have been described for this gene, and at least one of the variants utilizes alternativepolyadenylation signals.[ 6]
^a b c GRCh38: Ensembl release 89: ENSG00000080298 –Ensembl , May 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000040929 –Ensembl , May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ Reith W, Ucla C, Barras E, Gaud A, Durand B, Herrero-Sanchez C, Kobr M, Mach B (Feb 1994)."RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins" .Mol Cell Biol .14 (2):1230– 44.doi :10.1128/mcb.14.2.1230 .PMC 358479 PMID 8289803 . ^a b "Entrez Gene: RFX3 regulatory factor X, 3 (influences HLA class II expression)" .Emery P, Durand B, Mach B, Reith W (1996)."RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom" .Nucleic Acids Res .24 (5):803– 7.doi :10.1093/nar/24.5.803 .PMC 145730 PMID 8600444 . Iwama A, Pan J, Zhang P, et al. (1999)."Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains" .Mol. Cell. Biol .19 (6):3940– 50.doi :10.1128/mcb.19.6.3940 .PMC 104353 PMID 10330134 . Morotomi-Yano K, Yano K, Saito H, et al. (2002)."Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members" .J. Biol. Chem .277 (1):836– 42.doi :10.1074/jbc.M108638200 PMID 11682486 . Nakayama A, Murakami H, Maeyama N, et al. (2003)."Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter" .J. Biol. Chem .278 (1):233– 40.doi :10.1074/jbc.M209574200 PMID 12411430 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" .Proc. Natl. Acad. Sci. U.S.A .99 (26):16899– 903.Bibcode :2002PNAS...9916899M .doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Maijgren S, Sur I, Nilsson M, Toftgård R (2004). "Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element".Arch. Dermatol. Res .295 (11):482– 9.doi :10.1007/s00403-004-0456-5 .PMID 15024578 .S2CID 2408607 . Humphray SJ, Oliver K, Hunt AR, et al. (2004)."DNA sequence and analysis of human chromosome 9" .Nature .429 (6990):369– 74.Bibcode :2004Natur.429..369H .doi :10.1038/nature02465 .PMC 2734081 PMID 15164053 . Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" .Genome Res .14 (10B):2121– 7.doi :10.1101/gr.2596504 .PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature .437 (7062):1173– 8.Bibcode :2005Natur.437.1173R .doi :10.1038/nature04209 .PMID 16189514 .S2CID 4427026 . This article incorporates text from theUnited States National Library of Medicine , which is in thepublic domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4)β-Scaffold factors with minor groove contacts
(0) Other transcription factors
