DNA-binding protein RFX2 is aprotein that in humans is encoded by theRFX2gene.[5][6]
This gene is a member of the regulatory factor X gene family, which encodestranscription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is atranscriptional activator that can bindDNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of theIL-5 receptor alpha gene. Two transcript variants encoding differentisoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B (Sep 1992). "The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19".Genomics.13 (4):1307–10.doi:10.1016/0888-7543(92)90052-T.PMID1505960.
Maijgren S, Sur I, Nilsson M, Toftgård R (2004). "Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element".Arch. Dermatol. Res.295 (11):482–9.doi:10.1007/s00403-004-0456-5.PMID15024578.S2CID2408607.
