Regenerating islet-derived protein 3 alpha (or Regenerating islet-derived protein III-alpha) formerly known asHIP/PAP (Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-Associated Protein) and peptide 23[5] is aprotein that in humans is encoded by theREG3Agene.[6][7]
This gene encodes apancreaticsecretory protein that may be involved incell proliferation or differentiation. It has similarity to theC-type lectin superfamily. The enhancedexpression of this gene is observed during pancreaticinflammation andliver carcinogenesis. Multiple alternatively spliced transcript variants encoding the same protein have been described for this gene but the full length nature of some transcripts is not yet known.[7]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Chakraborty C, Sharma S, Katsumata N, Murphy LJ, Schroedter IC, Robertson MC, et al. (June 1995). "Plasma clearance, tissue uptake and expression of pituitary peptide 23/pancreatitis-associated protein in the rat".The Journal of Endocrinology.145 (3):461–469.doi:10.1677/joe.0.1450461.PMID7636430.
^Dusetti NJ, Frigerio JM, Fox MF, Swallow DM, Dagorn JC, Iovanna JL (January 1994). "Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene".Genomics.19 (1):108–114.doi:10.1006/geno.1994.1019.PMID8188210.
Lasserre C, Christa L, Simon MT, Vernier P, Bréchot C (September 1992). "A novel gene (HIP) activated in human primary liver cancer".Cancer Research.52 (18):5089–5095.PMID1325291.
Itoh T, Sawabu N, Motoo Y, Funakoshi A, Teraoka H (April 1995). "The human pancreatitis-associated protein (PAP)-encoding gene generates multiple transcripts through alternative use of 5' exons".Gene.155 (2):283–287.doi:10.1016/0378-1119(94)00799-X.PMID7721106.
Lasserre C, Simon MT, Ishikawa H, Diriong S, Nguyen VC, Christa L, et al. (August 1994). "Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer".European Journal of Biochemistry.224 (1):29–38.doi:10.1111/j.1432-1033.1994.tb19991.x.PMID8076648.
Christa L, Carnot F, Simon MT, Levavasseur F, Stinnakre MG, Lasserre C, et al. (December 1996). "HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells".The American Journal of Physiology.271 (6 Pt 1): G993-1002.doi:10.1152/ajpgi.1996.271.6.G993.PMID8997243.
Bödeker H, Keim V, Fiedler F, Dagorn JC, Iovanna JL (2000). "PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha".Molecular Cell Biology Research Communications.2 (3):150–154.doi:10.1006/mcbr.1999.0166.PMID10662590.
Lieu HT, Batteux F, Simon MT, Cortes A, Nicco C, Zavala F, et al. (September 2005). "HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice".Hepatology.42 (3):618–626.doi:10.1002/hep.20845.PMID16116631.S2CID10970433.
