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RDS-127

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
RDS-127
Structural formula of RDS-127
Ball-and-stick model of the RDS-127 molecule
Clinical data
ATC code
  • none
Identifiers
  • 4,7-dimethoxy-N,N-dipropyl-2,3-dihydro-1H-inden-2-amine
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC17H27NO2
Molar mass277.408 g·mol−1
3D model (JSmol)
  • CCCN(CCC)C1CC2=C(C=CC(=C2C1)OC)OC
  • InChI=1S/C17H27NO2/c1-5-9-18(10-6-2)13-11-14-15(12-13)17(20-4)8-7-16(14)19-3/h7-8,13H,5-6,9-12H2,1-4H3 ☒N
  • Key:FPAHQTSJKYIURQ-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

RDS-127 is adrug which is used inscientific research. It acts as aD2-like receptoragonist[1] and also has someserotonin andadrenergic agonist effects,[2][3][4][5] as well as someanticholinergic action,[6][7] and produces bothanorectic andpro-sexual effects in animal studies.[8][9]

See also

[edit]

References

[edit]
  1. ^Arnerić SP, Long JP, Williams M, et al. (January 1983)."RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane): central effects of a new dopamine receptor agonist".The Journal of Pharmacology and Experimental Therapeutics.224 (1):161–70.PMID 6401334.
  2. ^Arnerić SP, Roetker A, Long JP, Mott J, Barfknecht CF (June 1982). "Effects of semirigid methoxamine analogs on vascular smooth muscle: studies of methoxy-2-aminotetralin and 2-aminoindane derivatives".Archives Internationales de Pharmacodynamie et de Thérapie.257 (2):263–73.PMID 7114973.
  3. ^Arnerić SP, Long JP (May 1984). "Evidence that a novel dopamine receptor agonist, RDS-127 [2-di-n-propylamino-4,7-dimethoxyindane] has some centrally mediated cardiovascular actions".The Journal of Pharmacy and Pharmacology.36 (5):318–21.doi:10.1111/j.2042-7158.1984.tb04382.x.PMID 6145768.S2CID 24354158.
  4. ^Clark JT, Smith ER (1986)."Failure of pimozide and metergoline to antagonize the RDS-127-induced facilitation of ejaculatory behavior".Physiology & Behavior.37 (1):47–52.doi:10.1016/0031-9384(86)90382-3.PMID 3737722.S2CID 24423685.
  5. ^Rezaki YE, Ilhan M (1991). "Evaluation of alpha-adrenoceptor agonistic activity of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in rabbit and rat aortae".Archives Internationales de Pharmacodynamie et de Thérapie.310:76–86.PMID 1685313.
  6. ^Sahin I, Ilhan M (1988). "The antimuscarinic activity of a dopamine receptor agonist (RDS-127) differentiates M2-muscarinic receptors of heart, ileum and trachea in guinea-pig".Archives Internationales de Pharmacodynamie et de Thérapie.296:163–72.PMID 2907277.
  7. ^Sahin I, Tuncer M, Ilhan M (March 1990). "Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice".Archives Internationales de Physiologie et de Biochimie.98 (1):7–9.doi:10.3109/13813459009115730.PMID 1692697.
  8. ^Arnerić SP, Roetker A, Long JP (September 1982). "Potent anorexic-like effects of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in the rat: a comparison with other dopamine-receptor agonists".Neuropharmacology.21 (9):885–90.doi:10.1016/0028-3908(82)90080-6.PMID 6897285.S2CID 12005863.
  9. ^Kwong LL, Smith ER, Davidson JM, Peroutka SJ (October 1986). "Differential interactions of "prosexual" drugs with 5-hydroxytryptamine1A and alpha 2-adrenergic receptors".Behavioral Neuroscience.100 (5):664–8.doi:10.1037/0735-7044.100.5.664.PMID 2877677.
D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists
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