The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this protein suggest that this protein may act as a transcriptional coactivator for JUN/AP-1 and estrogen receptors. Multiple transcript variants encoding different isoforms have been observed for this gene.[6]
Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region".Genomics.83 (1):153–67.doi:10.1016/S0888-7543(03)00235-0.PMID14667819.
Sun NN, Fastje CD, Wong SS, Sheppard PR, Macdonald SJ, Ridenour G, Hyde JD, Witten ML (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line".Toxicology and Industrial Health.19 (7–10):157–63.doi:10.1191/0748233703th185oa.PMID15747776.S2CID14394243.
