This gene is a member of theglycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. Apseudogene exists on chromosome 1. Alternate transcriptional splice variants, encoding differentisoforms, have been characterized.[5] RBM3 contains apoison exon whose inclusion is lowered duringhypothermia.[6]
RBM3 is cold-induced RNA binding protein and is involved in mRNA biogenesis exerts anti-apoptotic effects.[7] According toantibody-based profiling andtranscriptomics analysis, RBM3 protein is present in all analysed human tissues[8] and based onconfocal microscopy mainly localised to thenucleoplasm.[9]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Derry JM, Kerns JA, Francke U (December 1995). "RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain".Human Molecular Genetics.4 (12):2307–11.doi:10.1093/hmg/4.12.2307.PMID8634703.
Danno S, Nishiyama H, Higashitsuji H, Yokoi H, Xue JH, Itoh K, Matsuda T, Fujita J (July 1997). "Increased transcript level of RBM3, a member of the glycine-rich RNA-binding protein family, in human cells in response to cold stress".Biochemical and Biophysical Research Communications.236 (3):804–7.doi:10.1006/bbrc.1997.7059.PMID9245737.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry".Analytical Chemistry.76 (10):2763–72.doi:10.1021/ac035352d.PMID15144186.
Dellis S, Strickland KC, McCrary WJ, Patel A, Stocum E, Wright CF (November 2004). "Protein interactions among the vaccinia virus late transcription factors".Virology.329 (2):328–36.doi:10.1016/j.virol.2004.08.017.hdl:10161/15063.PMID15518812.
Ong SE, Mittler G, Mann M (November 2004). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC".Nature Methods.1 (2):119–26.doi:10.1038/nmeth715.PMID15782174.S2CID6654604.
Martínez-Arribas F, Agudo D, Pollán M, Gómez-Esquer F, Díaz-Gil G, Lucas R, Schneider J (April 2006). "Positive correlation between the expression of X-chromosome RBM genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human breast cancer".Journal of Cellular Biochemistry.97 (6):1275–82.doi:10.1002/jcb.20725.PMID16552754.S2CID9804734.
