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RB-3007

From Wikipedia, the free encyclopedia
RB-3007
Names
IUPAC name
BenzylN-{(2S)-2-[([2-(acetylsulfanyl)ethoxy]{[(R)-amino(phenyl)methyl]phosphonoyl})methyl]-3-([1,1′-biphenyl]-4-yl)propanoyl}-L-alaninate
Systematic IUPAC name
Benzyl (9S,12S)-7-[(R)-amino(phenyl)methyl]-9-[([1,1′-biphenyl]-4-yl)methyl]-12-methyl-2,7,10-trioxo-6-oxa-3-thia-11-aza-7λ5-phosphatridecan-13-oate
Other names
RB3007, LS-15768
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C37H41N2O6PS/c1-27(37(42)44-25-30-12-6-3-7-13-30)39-36(41)34(24-29-18-20-32(21-19-29)31-14-8-4-9-15-31)26-46(43,45-22-23-47-28(2)40)35(38)33-16-10-5-11-17-33/h3-21,27,34-35H,22-26,38H2,1-2H3,(H,39,41)/t27-,34+,35+,46?/m0/s1
    Key: PYJMLILRVYLUHW-UNCDKACKSA-N
  • C[C@H](NC(=O)[C@H](CC1=CC=C(C=C1)C1=CC=CC=C1)CP(=O)(OCCSC(C)=O)[C@@H](N)C1=CC=CC=C1)C(=O)OCC1=CC=CC=C1
Properties
C37H41N2O6PS
Molar mass672.78 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

RB-3007 is an orally active analogue ofRB-101. It acts as anenkephalinase inhibitor, which is used in scientific research.[1][2]

See also

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References

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  1. ^Thanawala, V.; Kadam, V.; Ghosh, R. (1 October 2008). "Enkephalinase Inhibitors: Potential Agents for the Management of Pain".Current Drug Targets.9 (10):887–894.doi:10.2174/138945008785909356.PMID 18855623.
  2. ^Noble, Florence; Roques, Bernard P (17 January 2007). "Protection of endogenous enkephalin catabolism as natural approach to novel analgesic and antidepressant drugs".Expert Opinion on Therapeutic Targets.11 (2):145–159.doi:10.1517/14728222.11.2.145.PMID 17227231.S2CID 24437682.
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