RAR-related orphan receptor beta (ROR-beta), also known asNR1F2 (nuclear receptor subfamily 1, group F, member 2) is anuclear receptor that in humans is encoded by theRORB gene.[5]
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer tohormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact withNM23-2, anucleoside-diphosphate kinase involved in organogenesis and differentiation.[6]
In the brain, ROR-beta is concentrated in layer 4 of the cerebral cortex, where it plays a role in the development of structures such as barrel columns.[7]
A mutation in this gene also results in the loss of spinal cord interneurons and of saltatorial locomotion,[8] a type of hopping gait that in mammals can be found in rabbits, hares, kangaroos, and some species of rodents.
^Paravicini G, Steinmayr M, André E, Becker-André M (October 1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily".Biochemical and Biophysical Research Communications.227 (1):82–87.doi:10.1006/bbrc.1996.1471.PMID8858107.
Beeson WM, Perry TW, Zurcher TD (July 1977). "Effect of supplemental zinc on growth and on hair and blood serum levels of beef cattle".Journal of Animal Science.45 (1):160–165.doi:10.2527/jas1977.451160x.PMID885817.
Paravicini G, Steinmayr M, André E, Becker-André M (October 1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily".Biochemical and Biophysical Research Communications.227 (1):82–87.doi:10.1006/bbrc.1996.1471.PMID8858107.
Park HT, Baek SY, Kim BS, Kim JB, Kim JJ (October 1996). "Developmental expression of 'RZR beta, a putative nuclear-melatonin receptor' mRNA in the suprachiasmatic nucleus of the rat".Neuroscience Letters.217 (1):17–20.doi:10.1016/S0304-3940(96)13060-3 (inactive 1 July 2025).PMID8905729.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)
Gawlas K, Stunnenberg HG (December 2000). "Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1)".Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.1494 (3):236–241.doi:10.1016/s0167-4781(00)00237-2.PMID11121580.
Stehlin-Gaon C, Willmann D, Zeyer D, Sanglier S, Van Dorsselaer A, Renaud JP, et al. (October 2003). "All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta".Nature Structural Biology.10 (10):820–825.doi:10.1038/nsb979.PMID12958591.S2CID10108247.
