Receptor activity modifying protein 2, also known asRAMP2, is aprotein which in humans is encoded by theRAMP2gene.[5][6]
The protein encoded by this gene is a member of theRAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellularN-terminus and a cytoplasmicC-terminus. RAMPs are required to transportcalcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either acalcitonin gene-related peptide (CGRP) receptor or anadrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as anadrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.[5]
This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.
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